15131-89-2

Usage

Uses

Used in Organic Chemistry:
Benzeneacetaldehyde, a-[(dimethylamino)methylene]is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows for versatile chemical reactions, making it a valuable component in the preparation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Benzeneacetaldehyde, a-[(dimethylamino)methylene]is used as a key intermediate in the production of various drugs. Its ability to form imines and other nitrogen-containing compounds makes it an essential building block for the development of new pharmaceutical agents.
Used in Chemical Reactions:
Benzeneacetaldehyde, a-[(dimethylamino)methylene]is used as a reagent in chemical reactions, particularly in the formation of imines. Imines are important intermediates in organic synthesis and can be further transformed into a variety of nitrogen-containing compounds, such as amines, amides, and nitriles.
Used in Drug Development:
In drug development, Benzeneacetaldehyde, a-[(dimethylamino)methylene]plays a crucial role in the synthesis of potential drug candidates. Its unique chemical properties enable the creation of novel molecular structures with potential therapeutic applications, contributing to the discovery of new medicines for various diseases and conditions.

InChI:InChI=1/C11H13NO/c1-12(2)8-11(9-13)10-6-4-3-5-7-10/h3-9H,1-2H3/b11-8+

Upstream product

• 75-44-5 phosgene 
• 6314-97-2 1,1-diethoxy-2-phenylethane 
• 68-12-2 N,N-dimethyl-formamide 
• 103-82-2 phenylacetic acid 
• 122-78-1 phenylacetaldehyde 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 53913-71-6 3-chloro-2-phenylpropenal 
• 26591-66-2 2-phenyl-1,3-propanedial 
• 27568-26-9 2-furan-2-yl-5-phenyl-pyrimidine 
• 92707-27-2 3-Brom-2-phenyl-acrylaldehyd 
• 85128-54-7 3-cyano-5-phenylpyridine-2(1H)-thione 
• 10199-68-5 4-phenyl-1H-pyrazole 
• 71598-83-9 7,16-diphenyldibenzo<1,4,8,11>-tetraaza<14>annulene 
• 174720-39-9 2-(4-bromophenyl)-5-phenylpyrimidine 
• 936-46-9 4-Phenyl-isothiazole 
• 85128-55-8 1,2-dihydro-5-phenyl-2-thioxo-3-pyridinecarboxylic acid 
• 156896-58-1 C₁₂H₇Cl₂NOS 
• 82695-75-8 4-phenyl-1-(phenylsulfonyl)-1H-pyrazole 
• 82695-76-9 5-Allyl-1-benzenesulfonyl-4-phenyl-1H-pyrazole 
• 82695-77-0 Toluene-4-sulfonic acid 3-(2-benzenesulfonyl-4-phenyl-2H-pyrazol-3-yl)-propyl ester 

Relevant academic research and scientific papers

Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

The heme enzyme indoleamine 2,3-dioxygenase 1 (IDO1) plays an essential role in immunity, neuronal function, and aging through catalysis of the rate-limiting step in the kynurenine pathway of tryptophan metabolism. Many IDO1 inhibitors with different chemotypes have been developed, mainly targeted for use in anti-cancer immunotherapy. Lead optimization of direct heme iron-binding inhibitors has proven difficult due to the remarkable selectivity and sensitivity of the heme-ligand interactions. Here, we present experimental data for a set of closely related small azole compounds with more than 4 orders of magnitude differences in their inhibitory activities, ranging from millimolar to nanomolar levels. We investigate and rationalize their activities based on structural data, molecular dynamics simulations, and density functional theory calculations. Our results not only expand the presently known four confirmed chemotypes of sub-micromolar heme binding IDO1 inhibitors by two additional scaffolds but also provide a model to predict the activities of novel scaffolds.

Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)

Tryptophan 2,3-dioxygenase 2 (TDO2) catalyzes the conversion of tryptophan to the immunosuppressive metabolite kynurenine. TDO2 overexpression has been observed in a number of cancers; therefore, TDO inhibition may be a useful therapeutic intervention for

Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans

Potential inhibitors of Leptosphaeria maculans mediated detoxification of the phytoalexin brassilexin were designed and synthesized based on the planar heteroaromatic structure of isothiazolo[5,4-b]indole. Screening of these compounds for inhibition of br

A SYNTHESIS OF WITHASOMNINE FROM 4-PHENYLPYRAZOLE

Withasomnine (5), a pyrazole alkaloid isolated from Withania somnifera Dun.(Solanaceae), has been synthesized from 4-phenylpyrazole(1), a compound with potential symmetry.