151384-13-3Relevant academic research and scientific papers
Synthesis of the phosphoramidite derivative of 2′-deoxy-2′-C-β-methylcytidine
Li, Nan-Sheng,Piccirilli, Joseph A.
, p. 6799 - 6802 (2003)
2′-Deoxy-2′-C-β-methylnucleosides elicit interest as potential therapeutic agents and as analogues for the analysis of nucleic acid structure and function. An efficient route for the synthesis of 2′-deoxy-2′-C-methyluridine (11), 2′-deoxy-2′-C-methylcytidine (12), and the phosphoramidite derivative of 2′-deoxy-2′-C-β-methylcytidine (10, 46% overall yield) from 1,2,3,5-tetra-O-benzoyl-2-C-β-methylribofuranose (1) is described.
