1514-09-6

Basic information

• Product Name: Benzenecarbothioic acid, 4-(trifluoromethyl)-
• CAS NO: 1514-09-6
• Molecular Formula: C8H5F3OS
• Molecular Weight: 206.188
• Mol File: 1514-09-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenecarbothioic acid, 4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarbothioic acid, 4-(trifluoromethyl)-(1514-09-6)
• EPA Substance Registry System: Benzenecarbothioic acid, 4-(trifluoromethyl)-(1514-09-6)

Safety Data

• Hazardous Substances Data: 1514-09-6(Hazardous Substances Data)

Upstream product

• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 

Downstream Products

• 317318-97-1 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole 
• 317318-96-0 [4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol 
• 175277-03-9 4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester 
• 1571113-51-3 S-(4-trifluoromethylbenzoyl)thiohydroxylamine 
• 1259992-55-6 C₆H₄CF₃COSNHCOC₆H₅ 

Relevant articles and documents

Controllable thioester-based hydrogen sulfide slow-releasing donors as cardioprotective agents

Hydrogen sulfide (H2S) is an important signaling molecule with promising protective effects in many physiological and pathological processes. However, the study of H2S has been impeded by the lack of appropriate H2S donors that could mimic its slow-releasing process in vivo. Herein, we report the rational design, synthesis, and biological evaluation of a series of thioester-based H2S donors. These cysteine-activated H2S donors release H2S in a slow and controllable manner. Most of the donors comprising an allyl moiety showed significant cytoprotective effects in H9c2 cellular models of oxidative damage. The most potent donor 5e decreased the mitochondrial membrane potential (MMP) loss and lactate dehydrogenase (LDH) release in H2O2-stimulated H9c2 cells. More importantly, donor 5e exhibited a potent cardioprotective effect in an in vivo myocardial infarction (MI) mouse model by reducing myocardial infarct size and cardiomyocyte apoptosis. Taken together, our studies demonstrated that these new allyl thioesters are potential cardioprotective agents by releasing H2S.