15142-89-9

Usage

Chemical structure

A spiro-compound containing both isoquinoline and piperidine rings.

Benzyl group

Attached to the spiro-center, making it suitable for chemical modifications.

Application

Commonly used in medicinal chemistry and drug development.

Biological activity

Potential therapeutic agent for neurological and psychiatric disorders.

Pharmacological properties

The unique structure and potential activity make it a valuable target for further research and drug development efforts.

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 103-81-1 Benzeneacetamide 

Downstream Products

• 15142-87-7 3-oxo-3,4-dihydrospiro 
• 909035-11-6 1'-benzyl-4-methyl-2H-spiro[isoquinoline-1,4'-piperidin]-3(4H)-one 
• 909034-84-0 1‘-benzyl-2-methyl-3,4-dihydro-2H-spiro[isoquinoline-1,4’-piperidine] 

Relevant academic research and scientific papers

TRPML MODULATORS

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

SPIRO-ISOQUINOLINE-1,4'-PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

The present invention relates to spiro-isoquinoline-1,4'-piperidine compounds having dual pharmacological activity towards both the sigma (σ) receptor and the μ-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1

This invention relates to novel compounds of the Formulae I or II and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD l in mammals.Formula (I).

NPY antagonists: spiroisoquinolinone derivatives

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of spiroisoquinolinone derivatives of Formula I. As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.