15145-58-1

Upstream product

• 2983-48-4 1-phenyl-3-(phenylamino)propan-1-one 
• 935-06-8 N-(2-chloroethyl)aniline 
• 100-52-7 benzaldehyde 
• 92249-42-8 N-Phenyl-2-phenylsulfanylethylamine 
• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 
• 35280-80-9 β-phenylamino-propiophenone hydrochloride 
• 62-53-3 aniline 
• 81016-31-1 3-anilino-3-methylthio-1-phenylprop-2-en-1-one 

Downstream Products

• 95886-23-0 2-Aziridin-1-yl-3,6-diphenyl-[1,3,2]oxazaphosphinane 2-oxide 
• 95886-25-2 Bis-(2-chloro-ethyl)-(2-oxo-3,6-diphenyl-2λ⁵-[1,3,2]oxazaphosphinan-2-yl)-amine 
• 89410-02-6 2-chloro-3,6-diphenyltetrahydro-1,3,2-oxazaphosphorin-2-oxide 

Relevant academic research and scientific papers

Selective hydrogenation of aromatic aminoketones by Pd/C catalysis

We report an alternative hydrogenation of aromatic aminoketones by heterogeneous catalyst of palladium on carbon (Pd/C) in which nitro, in particular carbonyl groups in the ketones, could be selectively transformed to corresponding amino ketone, secondary alcohol, or methylene compound. Copyright Taylor & Francis Group, LLC.

Functionalized organolithium compounds of DTBB-catalyzed sulfur-lithium exchange

The successive reaction of β- or γ-hydroxy or amino phenyl thioethers (1,4) with butyllithium and an excess of lithium powder in the presence of a catalytic amount of DTBB in THF at - 78°C leads to the formation of the corresponding β- or γ-functionalized organolithium compounds 2 or 5, respectively, which by treatment with different electrophiles [D2O, t- BuCHO, PhCHO, Me2CO, (CH2)4CO, (CH2)5CO] at temperatures ranging between - 78°C and room temperature yields, after hydrolysis with water, the expected functionalized alcohols or amines 3 or 6, respectively, in a completely regioselective manner.

β-Functionalised organolithium compounds through a sulfur-lithium exchange

The successive reaction of different β-hydroxy or β-amino tbioethers 1a-d with n-butyl-lithium and an excess of lithium powder and a catalytic amount of DTB in THF at -78°C leads to the formation of the corresponding β-functionalised organolithium compounds 2a-d, which by reaction with several electrophiles [D2O, Bu(t)CHO, PhCHO, Me2CO, (CH2)5CO] at temperatures ranging between -78 and 20°C yields, after hydrolysis with water, the expected functionalised alcohols or amines 3aa-de in a regioselective manner.

N,2-Dilithioalkylamines from Aziridines by Naphthalene-Catalyzed Reductive Opening. Synthetic Applications

The reductive opening of aziridines 1a-c with lithium in the presence of a catalytic amount of naphthalene at -78 deg C led to the corresponding dianionic intermediates 2a-c, which are stable species under these reaction conditions and react with electrophilic reagents , (EtO)2CO, CH2=CHCO2Me, , PhCH=NPh, MeI, and CH2=CHCH2Br> to give, after hydrolysis with water, the corresponding difunctionalized compounds 3-5.When the reductive opening and the reaction with electrophiles were carried out on chiral aziridines 8 and 9, enantiomerically pure difunctionalized compounds 12 were obtained with the same stereochemistry, independently of the stereochemistry of diastereomeric starting aziridines 8 and 9.

AMINOAMIDES WITH AN ARYLAMINE GROUP. SYNTHESIS AND MASS SPECTRA

Aminoamides of the propane series with an arylamine fragment were synthesized by transamination of β-dimethylaminopropiophenone with various aromatic amines followed by reduction and condensation of the obtained amino alcohols with benzonitrile.A mass-spe

Synthesis of Heterocyclic Compounds: Part XXVII - Synthesis of 3,6-Diaryl and Alkyl/Aryltetrahydro 1,3,2-Oxazaphosphorin-2-oxides

Hitherto unreported 1,3,2-oxazaphosphorin-2-oxides with diaryl and alkyl/aryl substituents at 3, 4, 5 and 6 positions have been synthesised starting from the appropriate substituted 3-arylamino-1-propanols.