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1-[5-O-(methylsulfonyl)pentofuranosyl]pyrimidine-2,4(1H,3H)-dione, commonly referred to as MSMPD, is a chemical compound characterized by a pyrimidine ring with a pentofuranosyl group at the 5-position and a methylsulfonyl group attached to the pentofuranosyl moiety. As a derivative of the nucleoside thymidine, MSMPD is synthesized through the reaction of thymidine with methylsulfonyl chloride. 1-[5-O-(methylsulfonyl)pentofuranosyl]pyrimidine-2,4(1H,3H)-dione is of significant interest in the pharmaceutical industry due to its potential applications in the development of nucleoside analogs for antiviral and anticancer therapies.

15147-67-8

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15147-67-8 Usage

Uses

Used in Pharmaceutical Industry:
MSMPD is utilized as a key intermediate in the synthesis of nucleoside analogs, which are compounds that have shown potential as antiviral and anticancer drugs. The unique structure of MSMPD, including its methylsulfonyl and pentofuranosyl groups, contributes to the biological activities of the nucleoside analogs it helps to create.
1. Used in Antiviral Drug Development:
MSMPD is used as a building block for the development of antiviral agents. Its derivatives have demonstrated the ability to interfere with viral replication processes, making them valuable in the creation of new antiviral medications.
2. Used in Anticancer Drug Development:
MSMPD is also employed in the synthesis of compounds that target cancer cells. The resulting nucleoside analogs have shown promise in inhibiting the growth of cancer cells and may be further developed into effective anticancer treatments.
3. Used in Research and Development:
MSMPD and its derivatives are valuable for ongoing research aimed at understanding their biological activities and potential mechanisms of action. This research is crucial for the advancement of pharmaceuticals targeting viral and cancerous diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 15147-67-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,1,4 and 7 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 15147-67:
(7*1)+(6*5)+(5*1)+(4*4)+(3*7)+(2*6)+(1*7)=98
98 % 10 = 8
So 15147-67-8 is a valid CAS Registry Number.

15147-67-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl methanesulfonate

1.2 Other means of identification

Product number -
Other names 3'-hydroxy-5,6,7,4'-tetramethoxyflavone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15147-67-8 SDS

15147-67-8Downstream Products

15147-67-8Relevant academic research and scientific papers

Synthesis of novel 5'-uridine-head amphiphiles as model for DNA molecular recognition

Tiecco, Matteo,Di Profio, Pietro,Germani, Raimondo,Savelli, Gianfranco

experimental part, p. 911 - 923 (2010/09/04)

Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed as DNA transfection agents. The synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization that occurs when uridine is functionalized in this position without using protecting groups in the uracil.

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