151540-98-6

Basic information

• Product Name: 1,2-diazepine dihydrochloride
• CAS NO: 151540-98-6
• Molecular Weight: 173.086
• Mol File: 151540-98-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-diazepine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-diazepine dihydrochloride(151540-98-6)
• EPA Substance Registry System: 1,2-diazepine dihydrochloride(151540-98-6)

Safety Data

• Hazardous Substances Data: 151540-98-6(Hazardous Substances Data)

Usage

Chemical class

Diazepine derivatives

Common use

Intermediate in the synthesis of pharmaceuticals and organic compounds

Structural feature

Two chlorine atoms attached to the diazepine ring

Salt form

Dihydrochloride

Physical state

Crystalline solid

Molecular weight

184.05 g/mol

Chemical reactions

Condensation, oxidation, and reduction

Safety precautions

Potential skin and eye irritation; use in well-ventilated area with proper protective equipment

Upstream product

• 939964-15-5 di-tert-butyl 1,2-diazepane-1,2-dicarboxylate 
• 111-24-0 1,5-dibromo-pentane 

Relevant articles and documents

Synthesis, biological evaluation and structural determination of β-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors

Inhibitors of dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes. A series of β-aminoacyl-containing cyclic hydrazine derivatives were synthesized and evaluated as DPP-IV inhibitors. One member of this series, (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl)but an-1-one (10f), showed potent in vitro activity, good selectivity and in vivo efficacy in mouse models. Also, the binding mode of compound 10f was determined by X-ray crystallography.

NAPHTHALENE DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR

The present invention relates to naphthalene derivatives of formula (I) that are modulators of the glucocorticoid receptor, and to processes for the preparation and use of the same.