151583-91-4Relevant academic research and scientific papers
Synthesis of trans-Configurated Spacered Nucleoside Analogues Comprising a Difluorocyclopropane Moiety
Csuk, René,Eversmann, Leo
, p. 997 - 1004 (2003)
A novel class of trans-configurated difluorinated cyclopropanoic nucleoside analogues containing a methylene spacer between the cyclopropane ring and the heterocycle has been prepared. Some of these compounds showed weak anti-HIV activity in preliminary s
Hydroamination versus Allylic Amination in Iridium-Catalyzed Reactions of Allylic Acetates with Amines: 1,3-Aminoalcohols via Ester-Directed Regioselectivity
Kim, Seung Wook,Wurm, Thomas,Brito, Gilmar A.,Jung, Woo-Ok,Zbieg, Jason R.,Stivala, Craig E.,Krische, Michael J.
supporting information, p. 9087 - 9090 (2018/08/03)
In the presence of a neutral dppf-modified iridium catalyst and Cs2CO3, linear allylic acetates react with primary amines to form products of hydroamination with complete 1,3-regioselectivity. The collective data, including deuterium labeling studies, corroborate a catalytic mechanism involving rapid, reversible acetate-directed aminoiridation with inner-sphere/outer-sphere crossover followed by turnover-limiting proto-demetalation mediated by amine.
Prostaglandin analogs
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, (2008/06/13)
Thromboxane receptor antagonist activity is exhibited by compounds of the formula STR1 wherein: V is --(CH 2) m --, --O--, or STR2 but if V is --O--or STR3 R 3 and R 4 must complete an aromatic ring; W is --(CH 2) 2 --, --CH CH-- or phenylene;X is a single bond, --CH CH--, --(CH 2) n --, or --O--(CH 2) n --; or X is branched alkylene or --O--branched alkylene wherein W is linked to Y through a chain n carbon atoms long;Y is --CO 2 H, --CO 2 alkyl, --CO 2 alkali metal, --CH 2 OH, --CONHSO 2 R 5, --CONHR 6, or --CH 2 -5-tetrazolyl;Z is O or NH;R 3 and R 4 are each independently hydrogen or alkyl or R 3 and R 4 together complete a ring optionally substituted through a ring carbon with a halo, lower alkyl, phenyl, halo (lower alkyl), halophenyl, oxo or hydroxyl group; and the remaining symbols are as defined in the specification.
