1516-38-7

Usage

Uses

Used in Developmental Biology Research:
1-(2-Ethoxyphenyl)-2-thiourea is used as an inhibitor in the process of melanin synthesis in zebrafish for the purpose of achieving lighter pigmentation. This lighter pigmentation facilitates easier visualization of internal structures during microscopic examination, which is crucial for developmental biology studies.
Used in Scientific Research:
1-(2-Ethoxyphenyl)-2-thiourea is used as a research chemical, particularly in the context of organosulfur compounds, to explore its properties and potential applications in various scientific fields. Its solubility in organic solvents, as opposed to water, is a characteristic that may be relevant for certain research applications.
Safety Considerations:
Due to its chemical nature, 1-(2-Ethoxyphenyl)-2-thiourea should be handled with care, as it may pose certain health risks upon exposure. Proper safety measures and protocols should be followed to minimize any potential hazards associated with its use in research settings.

InChI:InChI=1/C9H12N2OS/c1-2-12-8-6-4-3-5-7(8)11-9(10)13/h3-6H,2H2,1H3,(H3,10,11,13)

Upstream product

• 333-20-0 potassium thioacyanate 
• 94-70-2 ortho-phenitidine 
• 23163-84-0 1-ethoxy-2-isothiocyanato-benzene 
• 1147550-11-5 ammonium thiocyanate 
• 89808-01-5 2-ethoxyaniline hydrochloride 
• 83697-74-9 N-<2-Ethoxy-phenyl>-N'-benzoyl-thioharnstoff 

Downstream Products

• 104510-08-9 (2-ethoxy-phenyl)-(4-methyl-thiazol-2-yl)-amine 
• 31102-75-7 (2-ethoxy-phenyl)-(6-nitro-thiazolo[4,5-b]quinoxalin-2-yl)-amine 
• 31102-88-2 3-(2-ethoxy-phenyl)-6-nitro-3H-thiazolo[4,5-b]quinoxalin-2-ylideneamine 
• 115541-04-3 2-(o-ethoxyphenylamino)-4-(2'-pyrazinyl)thiazole 
• 15850-79-0 2-amino-4-ethoxybenzothiazole 
• 76488-50-1 (2-Ethoxy-phenyl)-(4,5,6,7-tetrahydro-benzothiazol-2-yl)-amine 
• 1050503-63-3 4-(2-(2-ethoxyphenylamino)thiazol-4-yl)benzonitrile 
• 333746-69-3 C₁₅H₁₆N₄OS₂ 
• 1050503-47-3 4-(4-(1H-tetrazol-5-yl)phenyl)-N-(2-ethoxyphenyl)thiazol-2-amine 
• 1320342-84-4 C₂₀H₁₉N₃O₂S 
• 89808-06-0 (5-Ethoxy-3-phenyl-4H-benzo[1,4]thiazin-2-yl)-phenyl-methanone 
• 89808-04-8 (4-Chloro-phenyl)-(5-ethoxy-3-methyl-4H-benzo[1,4]thiazin-2-yl)-methanone 
• 89808-03-7 (5-Ethoxy-3-methyl-4H-benzo[1,4]thiazin-2-yl)-phenyl-methanone 
• 91074-49-6 2-amino-3-ethoxy-benzenethiol 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

Design and synthesis of N-Aryl isothioureas as a novel class of gastric H+/K+-ATPase inhibitors

To find new H+/K+-ATPase inhibitors for the treatment of peptic ulcer disease, a series of novel N-aryl isothiourea derivatives were synthesized and their structures were identified by 1H NMR and GC-MS. The effects of these compounds on inhibiting gastric acid secretion were evaluated by the guinea pig stomach mucous membrane study with pantoprazole magnesium as a positive control. The results showed that, of the 37 N-aryl isothiourea compounds synthesized, 20 compounds have comparable or stronger gastric acid inhibitory activities than that of pantoprazole magnesium. The quantitative structure-activity relationships (QSARs) of the N-aryl isothiourea compounds were also studied by comparative molecular field analysis (CoMFA) computation, and the model structure that was supposed to give more powerful bioactivities was finally predicted. A series of novel N-aryl isothiourea derivatives were synthesized and evaluated for their effects of inhibiting gastric acid secretion using the guinea pig stomach mucous membrane study with pantoprazole magnesium as a positive control. Compounds 2c, 2e, and 2k have higher bioactivity. The quantitative structure-activity relationships also defined these structural requirements.

Design and synthesis of new derivatives of 3H-quinazolin-4-one as potential anticonvulsant agents

As a part of systematic investigation on synthesis and biological activities, some new derivatives of 2-ethyl-3-(substituted benzothiazole- 2′-yl)-[3H]-quinazolin-4-ones 3 have been synthesized, and the structures of the compounds were confirmed by elemental analysis and spectral data. The newly synthesized derivatives are then screened for anticonvulsant activity by maximal electroshock method. Copyright

4′-Methyl-4,5′-bithiazole-based correctors of defective ΔF508-CFTR cellular processing

The synthesis and ΔF508-CFTR corrector activity of a 148-member methylbithiazole-based library are reported. Synthetic routes were devised and optimized to generate methylbithiazole analogs in four steps. Corrector potency and efficacy were assayed using epithelial cells expressing human ΔF508-CFTR. These structure-activity data establish that the bithiazole substructure plays a critical function; eight novel methylbithiazole correctors were identified with low micromolar potencies.

SYNTHESIS OF 2-AMINO-3-ETHOXYBENZENETHIOL AND ITS CONVERSION INTO 4H-1,4-BENZOTHIAZINES

Synthesis of 2-amino-3-ethoxybenzenethiol and 5-ethoxy-4H-1,4-benzothiazines is reported for the first time.Synthesis of 4H-1,4-benzothiazines involves the condensation and oxidative cyclization of 2-amino-3-ethoxybenzenethiol with β-diketones in DMSO.

Process for the manufacture of 2-amino-aryleno-thiazole compounds and of derivatives thereof N-substituted in the ring

2-Amino-aryleno-thiazoles in which the amino group in 2-position can be substituted by aryl, alkyl and/or cycloalkyl, and 2-imino-aryleno-thiazolines substituted at the ring nitrogen by aryl, alkyl or cycloalkyl are produced by cyclization of arylthioureas carrying corresponding substituents at the respective nitrogen atom, using thionyl chloride as cyclization agent. The advantage of the improved process resides in that the amount of sulfur formed is very low and that the other by-products are easy to separate and can be used further. The thiazoles and thiazolines are obtained in a high yield and purity. They are valuable starting compounds, especially for the manufacture of dyestuffs.