15161-07-6Relevant articles and documents
Benzenesulfonylation reagent as well as preparation method and application thereof
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, (2017/07/21)
The invention discloses a benzenesulfonylation reagent. The structure of the benzenesulfonylation reagent is shown as formula I in the specification, wherein R is a benzene ring connected with 0-5 substituents, and the substituents on the benzene ring are chlorine atoms, fluorine atoms, methyl groups or tert-butyl groups independently. The invention further discloses a preparation method and an application of the benzenesulfonylation reagent. The benzenesulfonylation reagent is prepared from methoxyamine hydrochloride and benzenesulfonyl chloride or a benzenesulfonyl chloride derivative through two steps of reactions, raw materials are cheap, a preparation process is simple, reaction conditions are mild, few side effects are produced, only extraction and simple column chromatographic purification are needed for aftertreatment, and the yield is high. The benzenesulfonylation reagent has higher benzenesulfonylation activity, benzenesulfonylation reaction conditions are mild, a reaction substrate range is wider, compounds such as alcohol, phenol, naphthol, thiophenol and the like can be subjected to a benzenesulfonylation reaction in presence of acetonitrile neutralized potassium carbonate, and -C1 does not exist on the benzenesulfonylation reagent, so that HCl gas with pungent odor cannot be emitted during application.
