1516866-75-3Relevant academic research and scientific papers
Palladium-catalyzed carbonylative α-arylation to β-ketonitriles
Schranck, Johannes,Burhardt, Mia,Bornschein, Christoph,Neumann, Helfried,Skrydstrup, Troels,Beller, Matthias
supporting information, p. 9534 - 9538 (2014/08/18)
A carbonylative α-arylation process employing unactivated nitriles for the first time is described. The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β-ketonitriles are obtained in good to excellent yields. The methodology also allows for a convenient 13C-labelling of the generated carbonyl moiety. Three COmponent α-arylation: A carbonylative α-arylation process employing nitriles for the first time is described (see scheme). The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β-ketonitriles are obtained in good to excellent yields. In addition, the methodology allows for a 13C-labelling of the generated carbonyl moiety.
