1646594-90-2Relevant academic research and scientific papers
Asymmetric Hydroacylation Involving Alkene Isomerization for the Construction of C3-Chirogenic Center
Liu, Chong,Yuan, Jing,Zhang, Zhenfeng,Gridnev, Ilya D.,Zhang, Wanbin
supporting information, p. 8997 - 9002 (2021/03/16)
A new transformation pattern for enantioselective intramolecular hydroacylation has been developed involving an alkene isomerization strategy. Proceeding through a five-membered rhodacycle intermediate, 3-enals were converted to C3- or C3,C5-chirogenic cyclopentanones with satisfactory yields, diastereoselectivities, and enantioselectivities. A catalytic cycle has been theoretically calculated and the origin of the stereoselection is rationally explained.
Palladium-catalyzed carbonylative α-arylation to β-ketonitriles
Schranck, Johannes,Burhardt, Mia,Bornschein, Christoph,Neumann, Helfried,Skrydstrup, Troels,Beller, Matthias
supporting information, p. 9534 - 9538 (2014/08/18)
A carbonylative α-arylation process employing unactivated nitriles for the first time is described. The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β-ketonitriles are obtained in good to excellent yields. The methodology also allows for a convenient 13C-labelling of the generated carbonyl moiety. Three COmponent α-arylation: A carbonylative α-arylation process employing nitriles for the first time is described (see scheme). The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β-ketonitriles are obtained in good to excellent yields. In addition, the methodology allows for a 13C-labelling of the generated carbonyl moiety.
