1516893-30-3Relevant academic research and scientific papers
A macrocyclic chelator with unprecedented Th4+ affinity
Pham, Tiffany A.,Xu, Jide,Raymond, Kenneth N.
, p. 9106 - 9115 (2014)
A novel macrocyclic octadentate ligand incorporating terephthalamide binding units has been synthesized and evaluated for the chelation of Th 4+. The thorium complex was structurally characterized by X-ray diffraction and in solution with kinetic studies and spectrophotometric titrations. Dye displacement kinetic studies show that the ligand is a much more rapid chelator of Th4+ than prevailing ligands (1,4,7,10- tetraazacyclododecane-1,4,7,10-tetraacetic acid and diethylenetriaminepentaacetic acid). Furthermore, the resulting complex was found to have a remarkably high thermodynamic stability, with a formation constant of 1054. These data support potential radiotherapeutic applications.
MACROCYCLES
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Paragraph 0217; 0218; 0219; 0220; 0221, (2015/06/17)
The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
