1516898-75-1Relevant academic research and scientific papers
TfNHNHBoc as a SCF3 source for the sulfenylation of indoles
Guo, Jing-Yu,Dai, Rui-Han,Xu, Wen-Cong,Wu, Ruo-Xin,Tian, Shi-Kai
supporting information, p. 8980 - 8982 (2018/08/21)
An unprecedented use of trifluoromethanesulfonyl hydrazides as effective SCF3 sources has been established in the sulfenylation of indoles. A range of substituted indoles participated in CuCl-catalyzed oxidative sulfenylation reaction with TfNHNHBoc in the presence of dimethyl sulfoxide to furnish structurally diverse 3-indolyl trifluoromethyl thioethers in moderate to good yields with very high regioselectivity.
Synthesis of 3-((trifluoromethyl)thio)indoles via a reaction of 2-alkynylaniline with trifluoromethanesulfanylamide
Sheng, Jie,Li, Shaoyu,Wu, Jie
supporting information, p. 578 - 580 (2014/01/06)
3-((Trifluoromethyl)thio)indoles can be synthesized by a palladium(ii)-catalyzed reaction of 2-alkynylaniline with trifluoromethanesulfanylamide in the presence of bismuth(iii) chloride. The presence of bismuth(iii) chloride is crucial for the success of this transformation, which activates the trifluoromethanesulfanylamide during the reaction. The Royal Society of Chemistry 2014.
