151695-69-1Relevant academic research and scientific papers
Efficient removal of pipecolinate from rapamycin and FK506 by reaction with n-Bu4N+CN-
Luengo, Juan I.,Rozamus, Leonard W.,Holt, Dennis A.
, p. 4599 - 4602 (1993)
The reaction of rapamycin (1) and FK506 (11) with n-Bu4N+CN- / aq. THF results in an efficient excision of their pipecolinate subunits, leading in good yields to compounds 3 and 12, respectively. Two sequential ring cleava
