Efficient removal of pipecolinate from rapamycin and FK506 by reaction with n-Bu4N+CN-

DOI: 10.1016/S0040-4039(00)60634-2

Source and publish data:

Tetrahedron Letters p. 4599 - 4602 (1993)

Update date:2022-08-03

Topics:

Authors:

Luengo, Juan I.

Rozamus, Leonard W.

Holt, Dennis A.

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Article abstract of DOI:10.1016/S0040-4039(00)60634-2

The reaction of rapamycin (1) and FK506 (11) with n-Bu₄N⁺CN^- / aq. THF results in an efficient excision of their pipecolinate subunits, leading in good yields to compounds 3 and 12, respectively. Two sequential ring cleava

Full text of DOI:10.1016/S0040-4039(00)60634-2

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