151697-01-7Relevant articles and documents
Nucleophilic aromatic substitution reactions with the fluoride ion: formation of 5-fluoroindanones and indandiones related to atipamezole
Enas, J. D.,Garcia, J. G.,Mathis, C. A.,Gerdes, J. M.
, p. 233 - 242 (1993)
The 5-nitro and 5-(trimethylammonium trifluoromethanesulfonyl)indanones 2a,b and the related 1,3-indandiones 3a,b have been synthesized, and the efficiency of the nucleophilic aromatic substitution reaction with fluoride ion on these substrates evaluated.The indandiones underwent aromatic substitution to afford fluoroaromatic adducts whereas the indanone substrates provided little or no fluoro-substitution product.The fluoroindandione was subsequently reduced to the corresponding fluoroindane hydrocarbon.The synthetic sequence of nucleophilic fluorination followedby carbonyl reduction provides a rationale for the potential preparation of the radiofluorinated α2-adrenoreceptor ligand 5-fluoroatipamezole.
KCNQ 2-5 CHANNEL ACTIVATOR
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Paragraph 0257, (2019/03/06)
An object of the present invention is to provide a novel compound having a strong opening action with respect to KCNQ2-5 channels. A compound represented by the general formula (I) (wherein the definition of each group is as described in the specification) is provided. The compound represented by the general formula (I) has a strong opening action with respect to KCNQ2-5 channels, and therefore is useful as a prophylactic and/or therapeutic agent for a KCNQ2-5 channel-related disease (for example, dysuria, overactive bladder, or the like).
