151697-35-7Relevant articles and documents
Asymmetric total synthesis of (-)-podophyllotoxin
Bush, Edward J.,Jones, David W.
, p. 151 - 155 (2007/10/03)
(-)-Podophyllotoxin of 98% optical purity has been synthesized in eight steps and in 15% overall yield. The key step, Diels-Alder addition of the o-quinonoid pyrone 2 [6,7-methylenedioxy-1-(3,4,5-trimethoxyphenyl)-2-benzopyran-3-one] to the chiral dienophile 5 [5-(-)-menthyloxyfuran-2(5H)-one], proceeds with very high regio-, endo- and facial selectivity.