116097-18-8Relevant academic research and scientific papers
Synthesis of Podophyllum Lignans via an Isolable o-Quinonoid Pyrone
Jones, David W.,Thompson, Adrian M.
, p. 1797 - 1798 (1987)
The 2-benzopyran-3-one (7) is a stable, isolable, and useful Diels-Alder diene; its adduct (10) formed with dimethyl fumarate is transformed in three steps into methyl epipodophyllate (14) which gives epipodophyllotoxin (2) (81percent) by direct lactonisation (ZnCl2-tetrahydrofuran-4 Angstroem molecular sieves).
Synthesis of Podophyllum Lignans via an Isolable o-Quinonoid Pyrone
Jones, David W.,Thompson, Adrian M.
, p. 2533 - 2540 (2007/10/02)
The 2-benzopyran-3-one 10 is a stable, isolable and useful Diels-Alder diene; its methyl 4-benzoyloxycrotonate adduct 23 formed regioselectively and stereoselectively in acetonitrile is reduced with H2/Pd to give 31 with inversion of C-1 stereochemistry.T
