116097-18-8

Upstream product

• 155004-78-7 methyl 3,4-methylenedioxy-6-(3',4',5'-trimethoxybenzoyl)phenylacetate 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 326-59-0 benzo[1,3]dioxol-5-yl-acetic acid methyl ester 
• 116097-17-7 3,4-methylenedioxy-6-(3',4',5'-trimethoxybenzoyl)phenylacetic acid 

Downstream Products

• 151697-35-7 C₃₃H₃₈O₁₀ 
• 477-51-0 (5S,5aS,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3′,4’:6,7]naphtho[2,3-d][1,3]-dioxol-6(5aH)-one 
• 1643-12-5 (5S,6S,7S)-7-Hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester 
• 42123-26-2 dimethyl 6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)naphthalene-2,3-dicarboxylate 
• 77519-37-0 9-hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 122763-50-2 methyl 3-(hydroxymethyl)-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-1,2-dihydronaphthalene-2-carboxylate 
• 477-47-4 (+/-)-epipodophyllotoxin 
• 1256-91-3 (+/-)-methyl epipodophyllate 
• 1256-91-3 methyl isopicropodophyllate 

Relevant academic research and scientific papers

Synthesis of Podophyllum Lignans via an Isolable o-Quinonoid Pyrone

The 2-benzopyran-3-one (7) is a stable, isolable, and useful Diels-Alder diene; its adduct (10) formed with dimethyl fumarate is transformed in three steps into methyl epipodophyllate (14) which gives epipodophyllotoxin (2) (81percent) by direct lactonisation (ZnCl2-tetrahydrofuran-4 Angstroem molecular sieves).

Synthesis of Podophyllum Lignans via an Isolable o-Quinonoid Pyrone

The 2-benzopyran-3-one 10 is a stable, isolable and useful Diels-Alder diene; its methyl 4-benzoyloxycrotonate adduct 23 formed regioselectively and stereoselectively in acetonitrile is reduced with H2/Pd to give 31 with inversion of C-1 stereochemistry.T