151698-49-6

Basic information

• Product Name: N,N-diethyl-2-methoxy-6-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]benzamide
• Synonyms: N,N-diethyl-2-methoxy-6-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]benzamide
• CAS NO: 151698-49-6
• Molecular Weight: 385.46
• Mol File: 151698-49-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-2-methoxy-6-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-2-methoxy-6-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]benzamide(151698-49-6)
• EPA Substance Registry System: N,N-diethyl-2-methoxy-6-[2-(3,4-dimethoxyphenyl)-2-oxoethyl]benzamide(151698-49-6)

Safety Data

• Hazardous Substances Data: 151698-49-6(Hazardous Substances Data)

Upstream product

• 6967-45-9 3,4-dimethoxy-N,N-dimethylbenzamide 
• 88430-97-1 N,N-diethyl-2-methoxy-6-methylbenzamide 

Downstream Products

• 147666-80-6 Thunberginol A 
• 147666-84-0 3-(3,4-dimethoxyphenyl)-8-methoxyisochromen-1-one 

Relevant articles and documents

Synthesis of 3-substituted isocoumarins and their inhibitory effects on degranulation of RBL-2H3 cells induced by antigen

Eleven 3-substituted isocoumarins and a benzylidenephthalide were synthesized through thermal cyclization reaction of δ- and γ-ketoamides, respectively. Subsequent deprotection of the hydroxyl groups of the resulting isocoumarin and benzylidenephthalide compounds afforded thunberginols A, B, and F., respectively, which originated from the processed leaves of Hydrangea macrophylla Seringe var. thunbergii MAKINO. The synthesized isocoumarins and thunberginols were evaluated for their anti-allergic activity, in which thunberginol B exhibited the highest inhibitory potency on the degranulation of RBL-2H3 cells induced by antigen. Structure - activity relationship studies were carried out to determine the necessary substituents on the 3-phenylisocoumarin skeleton for inhibitory activity.