29723-28-2

Usage

Uses

Used in Pharmaceutical Industry:
2,4,6-Trimethoxy-benzoic acid methyl ester is used as an active pharmaceutical ingredient for its potential health benefits, including its antioxidant, anti-inflammatory, and antimicrobial properties. It is being studied for its potential use in the development of new drugs that can address various health conditions.
Used in Flavoring and Fragrance Industry:
2,4,6-TRIMETHOXY-BENZOIC ACID METHYL ESTER is used as a flavoring agent and a fragrance component in the food and cosmetics industries, respectively. Its unique chemical structure contributes to the distinct taste and scent profiles in various products.
Used in Organic Synthesis:
2,4,6-Trimethoxy-benzoic acid methyl ester is used as a key intermediate in the synthesis of other organic compounds. Its versatile chemical properties make it a valuable building block for creating a wide range of chemical products.
Used as a Research Tool:
In the fields of chemistry and biochemistry, 2,4,6-Trimethoxy-benzoic acid methyl ester serves as a research tool for studying various chemical reactions and biological processes. Its unique properties allow scientists to explore new avenues in chemical synthesis and understand the mechanisms of various biological activities.

InChI:InChI=1/C11H14O5/c1-13-7-5-8(14-2)10(11(12)16-4)9(6-7)15-3/h5-6H,1-4H3

Upstream product

• 186581-53-3 diazomethane 
• 83-30-7 acide 2,4,6-trihydroxybenzoique 
• 77-78-1 dimethyl sulfate 
• 720698-36-2 2,2,2-trichloro-1-(2,4-dihydroxy-6-methoxy-phenyl)-ethanone 
• 570-02-5 2,4,6-trimethoxybenzoic acid 
• 74-88-4 methyl iodide 
• 51116-92-8 methyl 4,6-dimethoxysalicylate 
• 3147-39-5 methyl 2,4,6-trihydroxybenzoate 
• 7446-70-0 aluminium trichloride 
• 621-23-8 1,2,3-trimethoxybenzene 
• 79-22-1 methyl chloroformate 
• 67-64-1 acetone 
• 19722-76-0 methyl-2,6-dihydroxy-4-methoxybenzoate 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 

Downstream Products

• 570-02-5 2,4,6-trimethoxybenzoic acid 
• 685142-56-7 3-chloro-2,4,6-trimethoxy-benzoic acid methyl ester 
• 76631-05-5 1-(2,4,6-trimethoxyphenyl)-1,3,5,7-octanetetraone 
• 76631-01-1 1-(2,4,6-trimethoxyphenyl)-1,3,5-hexanetrione 
• 51116-92-8 methyl 4,6-dimethoxysalicylate 
• 914607-15-1 dimethyl 2-cyano-4,6-dimethoxy-1,3-benzenedicarboxylate 
• 914607-32-2 4,6-dimethoxy-2-trifluoromethanesulfonyloxy-isophthalic acid dimethyl ester 
• 914607-23-1 5-(2,5-dimethoxybenzyl)-7-methoxy-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid 
• 914607-22-0 methyl 5-(2,5-dimethoxybenzyl)-7-methoxy-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylate 
• 914607-27-5 methyl 5-[2,5-dimethoxy-3-(methoxymethyl)benzyl]-7-methoxy-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylate 
• 914607-12-8 5-[2,5-dimethoxy-3-(methoxymethyl)benzyl]-7-methoxy-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid 
• 914607-35-5 methyl 5-{2,5-dimethoxy-3-[(4-methoxybenzyloxy)methyl]benzyl}-7-methoxy-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylate 
• 914607-36-6 5-{2,5-dimethoxy-3-[(4-methoxybenzyloxy)methyl]benzyl}-7-methoxy-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid 
• 51116-93-9 3-Formyl-2-hydroxy-4,6-dimethoxy-benzoesaeuremethylester 

Relevant academic research and scientific papers

Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B

Irciniastatin A (a.k.a. psymberin) and irciniastatin B are members of the pederin natural product family, which have potent antitumor activity and structural complexity. Herein, we describe a full account of our total synthesis of (+)-irciniastatin A and (-)-irciniastatin B. Our synthesis features the highly regioselective Eu(OTf)3-catalyzed, DTBMP-assisted epoxide ring opening reaction with MeOH, which enabled a concise synthesis of the C1-C6 fragment, extensive use of AZADO (2-azaadamantane N-oxyl) and its related nitroxyl radical/oxoammonium salt-catalyzed alcohol oxidation throughout the synthesis, and a late-stage assembly of C1-C6, C8-C16, and C17-C25 fragments. In addition, for the synthesis of (-)-irciniastatin B, we achieved the C11-selective control of the oxidation stage via regioselective deprotection and AZADO-catalyzed alcohol oxidation. The synthetic irciniastatins showed high levels of cytotoxic activity against mammalian cells. Furthermore, chemical footprinting experiments using synthetic compounds revealed that the binding site of irciniastatins is the E-site of the ribosome.

INFECTION INDICATING MEDICAL DEVICES

Provided herein is an implantable medical device capable of self-reporting microbial growth adjacent the site of the implanted device.

Copper-catalyzed methyl esterification of aromatic aldehydes and benzoic alcohols by TBHP as both oxidant and methyl source

A copper-catalyzed synthesis of methyl esters from aromatic aldehydes in the presence of tert-butyl hydrogen peroxide (TBHP) was developed via a radical reaction mechanism. TBHP acts not only as an efficient oxidant, but also as a green methyl source in such transformation. Moreover, this method could also be efficiently extended to the methyl esterification of benzylic alcohols.

Synthesis of 8-desmethoxy psymberin: A putative biosynthetic intermediate towards the marine polyketide psymberin

The synthesis of a putative biosynthetic precursor of psymberin including a formal synthesis of the natural product is described. The key step towards the densely functionalized tetrahydropyran core was an enantioselective catalytic Mukaiyama aldol reacti

TRISUBSTITUTED METHYL ALCOHOLS AND THEIR POLYMERIZABLE DERIVATIVES

Provided herein are trisubstituted methyl alcohols, preferably pH indicators that are substituted with optionally substituted aryl and or optionally substituted heteroaryl groups, and optionally include one or more polymerizable substituents.

Indicators for detecting the presence of metabolic byproducts from microorganisms

Polymeric indicator films and pH indicating wraps are provided for visually monitoring, detecting, and/or determining the presence of metabolic byproducts from harmful or potentially harmful microorganisms. Also provided are methods of use and preparation of the polymeric indicator films.

INDICATORS FOR DETECTING THE PRESENCE OF METABOLIC BYPRODUCTS FROM MICROORGANISMS

Polymeric indicator films and pH indicating wraps are provided for visually monitoring, detecting, and/or determining the presence of metabolic byproducts from harmful or potentially harmful microorganisms. Also provided are methods of use and preparation of the polymeric indicator films.

Studies on the total synthesis of lactonamycin: Synthesis of the CDEF ring system

A concise and efficient synthesis of the tetracyclic CDEF ring system of lactonamycin (1) is described. The key step involved the Lewis acid mediated, intramolecular Friedel-Crafts acylation of carboxylic acid 6 to produce the tetracyclic CDEF core struct

Synthesis of 3-arylisocoumarins, including thunberginols A and B, unsymmetrical 3,4-disubstituted isocoumarins, and 3-ylidenephthalides via iodolactonization of methyl 2-ynylbenzoates or the corresponding carboxylic acids

3-Aryl-4-iodoisocoumarins, which were readily and efficiently prepared by regioselective iodolactonization of methyl 2-ynylbenzoates or the corresponding carboxylic acids, were used as precursors either to 3-arylisocoumarins, including naturally-occurring