151725-89-2

Upstream product

• 76-83-5 trityl chloride 
• 58-61-7 adenosine 
• 31085-55-9 (2R,3R,4S,5R)-2-(6-(tritylamino)-9H-purin-9-yl)-5-((trityloxy)methyl)tetrahydrofuran-3,4-diol 

Downstream Products

• 151725-91-6 N⁶-triphenylmethyl-9-(2,3-dideoxy-2-fluoro-β-D-erythro-pentofuranosyl)adenine 
• 151725-90-5 N⁶-triphenylmethyl-9-(2,3-dideoxy-2-fluoro-5-O-triphenylmethyl-β-D-erythro-pentofuranosyl)adenine 

Relevant academic research and scientific papers

Synthetic Approaches towards Nucleocidin and Selected Analogues; anti-HIV Activity in 4'-Fluorinated Nucleoside Derivatives

Nucleocidin 1 has been synthesised from the adenosine derivative 4 via the intermediacy of the dihalogeno compound 9.The latter compound showed slight but significant activity against HIV-infected cells while the isomer 10 and the monohalogeno compound 60 were inactive.Synthetic approaches towards other 4'-fluorinated nucleoside derivatives are also described.The epimeric 4'-fluorinated nucleosides 26 and 27 displayed similar activity against HIV-infected cells to that observed for the dihalogenated compound 9.