15173-99-6Relevant articles and documents
Basic ethers of cyclohexylphenols with β blocking activity. Synthesis and pharmacological study of exaprolol
Carissimi,Gentili,Grumelli,Milla,Picciola,Ravenna
, p. 506 - 516 (2007/10/06)
The paper discribes the preparation and study of the pharmacological properties of the basic ethers of cyclohexylphenols. The compounds with a single cycloaliphatic radical ortho to the basic chain, and in particular the one with a cyclohexyl (exaprolol), were found to be particularly active in blocking the β adrenergic receptors, as antiarrhythmics and local anesthetics, while the introduction of a second radical or the shift of the cycloaliphatic radical to meta or para position caused the said pharmacological activities to disappear almost entirely, with the exception of the local anesthetic action.
