4855-68-9

Usage

InChI:InChI=1/C13H18O/c1-10-6-5-9-12(13(10)14)11-7-3-2-4-8-11/h5-6,9,11,14H,2-4,7-8H2,1H3

Upstream product

• 95-48-7 ortho-cresol 
• 110-83-8 cyclohexene 
• 15173-99-6 6-Cyclohexyl-o-tolyl methylaether 
• 542-18-7 cyclohexyl chloride 
• 108-93-0 cyclohexanol 
• 7446-70-0 aluminium trichloride 
• 7637-07-2 boron trifluoride 
• 67698-81-1 1-(cyclohexyloxy)-2-methylbenzene 
• 108-94-1 cyclohexanone 
• 59334-09-7 2-Methyl-6-(cyclohexen-1-yl)-anisole 

Downstream Products

• 41468-67-1 2-cyclohexyl-4-dimethylaminomethyl-6-methyl-phenol 
• 956479-85-9 1-allyloxy-2-methyl-6-cyclohexylbenzene 
• 956479-94-0 4-allyl-2-methyl-6-cyclohexylphenol 
• 956479-65-5 butyl 3-(3-methyl-5-cyclohexyl-4-hydroxyphenyl)propyl sulfide 
• 109276-59-7 methyl 3-(3-cyclohexyl-4-hydroxy-5-methylphenyl)propionate 

Relevant academic research and scientific papers

Synthesis and antioxidant properties of sodium S-[3-(hydroxyaryl)propyl] thiosulfates and [3-(hydroxyaryl)propane]-1-sulfonates

Sodium S-[3-(hydroxyaryl)propyl] thiosulfates and [3-(hydroxyaryl)propane]- 1-sulfonates with various spatial hindrance of their phenolic OH groups were synthesized from dialkylphenols via a number of intermediate products. On a model reaction of oxidation of methyl oleate in aqueous sodium dodecyl sulfate, the rate constants of the interaction of the synthesized compounds with lipoperoxide radicals were determined.

ORTHO-ALKYLATION OF o-, m-, AND p-CRESOLS WITH CYCLOHEXENE IN THE PRESENCE OF ALUMINUM CRESOLATES

The reaction of o-, m-, and p-cresols with cyclohexene in the presence of the corresponding aluminum cresolates leads to mixtures of ethers and phenols, in which the ortho-alkylation products, formed with yields of 75-85percent, predominate.

Synthesis, Biological Evaluation, and Preliminary Structure-Activity Considerations of a Series of Alkylphenols as Intravenous Anesthetic Agents

Following our discovery of the intravenous (iv) anesthetic activity of 2,6-diethylphenol in mice, a series of alkylphenols was examined in this species and the most active analogues were further evaluated in rabbits.The synthesis of compounds which were not commercially available was accomplished by adaptations of standard ortho-alkylation procedures for phenols.Structure-activity relationships were found to be complex, but, in general, potency and kinetics appeared to be a function of both the lipophilic character and the degree of steric hindrance exerted by ortho substituents.The most interesting compounds were found in the 2,6-dialkyl series, and the greatest potency was associated with 2,6-di-sec-alkyl substitution.In particular, 2,6-diisopropylphenol (ICI 35868) emerged as a candidate for further development and has subsequently been shown to be an effective iv anesthetic agent in man.

Basic ethers of cyclohexylphenols with β blocking activity. Synthesis and pharmacological study of exaprolol

The paper discribes the preparation and study of the pharmacological properties of the basic ethers of cyclohexylphenols. The compounds with a single cycloaliphatic radical ortho to the basic chain, and in particular the one with a cyclohexyl (exaprolol), were found to be particularly active in blocking the β adrenergic receptors, as antiarrhythmics and local anesthetics, while the introduction of a second radical or the shift of the cycloaliphatic radical to meta or para position caused the said pharmacological activities to disappear almost entirely, with the exception of the local anesthetic action.