151745-47-0

Upstream product

• 50-30-6 2,6-dichlorobenzoic acid 
• 55775-97-8 2,6-dichloro-3-nitrobenzoic acid 

Downstream Products

• 137332-60-6 N-(2,6-Dichloro-3-nitrobenzoyl)-L-alaninamide 
• 934275-59-9 (2,6-dichloro-3-nitro-phenyl)-pyrrolidin-1-yl-methanone 
• 137332-56-0 (+)-(S)-N-(2,6-Dichloro-3-nitrobenzyl)-1,2-propanediamine 
• 137332-54-8 Tivirapine 
• 454471-77-3 6-chloro-2-hydroxy-3-nitrobenzamide 
• 454471-70-6 3-amino-6-chloro-2-hydroxy-benzamide 
• 454471-71-7 6-chloro-3-(2-chloro-3,4-dioxo-cyclobut-1-enylamino)-2-hydroxy-benzamide 
• 934275-51-1 3-chloro-6-nitro-2-(1-pyrrolidinylcarbonyl)phenol 
• 934275-43-1 6-amino-3-chloro-2-(1-pyrrolidinylcarbonyl)phenol 
• 55775-98-9 2,6-dichloro-3-nitrobenzoic acid amide 
• 106587-96-6 2,6-dichloro-N,N-dimethyl-3-nitrobenzamide 

Relevant academic research and scientific papers

Comparison of N,N′-diarylsquaramides and N,N′-diarylureas as antagonists of the CXCR2 chemokine receptor

N,N′-diarylsquaramides were prepared and evaluated as antagonists of CXCR2. The compounds were found to be potent and selective antagonists of CXCR2. Significant differences in SAR was observed relative to the previously described N,N′-diarylurea series. As was the case in the N,N′-diarylurea series, placing sulfonamide substituent adjacent to the acidic phenol significantly reduced the clearance in rat pharmacokinetic studies.

INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF

Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same.

MOLECULES HAVEING PESTICIDAL UTILIY AND INTERMEDIATES, COMPOSITIONS AND PROCESSES RELATED THERETO

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

Regioselectivity in Intramolecular Nucleophilic Aromatic Substitution. Synthesis of the Potent Anti HIV-1 8-Halo TIBO Analogues

Regioselective intramolecular nucleophilic substitution of 2,6-dihalo-3-nitrobenzyl diamines 2b and 2c gave benzodiazepines 3.These intermediates are useful in the preparation of the 8-halo TIBO derivatives 1, inhibitors of HIV-I replication in cell cultu

Chromatographic Separation of Enantiomers and Barriers to Enantiomerization of Axially Chiral Aromatic Carboxamides

The enantiomers (M) and (P) of a series of similar aromatic carboxamides have been, for the first time, investigated analytically and enriched preparatively by liquid chromatography on triacetylcellulose.Enantiomeric purities (7-99percent), specific rotations, and barriers to rotation about the C(sp2)-C(sp2) bond (87 - 120 kJ/mol, Table 5) were determined.These energies are discussed in terms of the size of ortho substituents and of the buttressing effects by meta substituents.