55775-98-9Relevant academic research and scientific papers
Comparison of N,N′-diarylsquaramides and N,N′-diarylureas as antagonists of the CXCR2 chemokine receptor
McCleland, Brent W.,Davis, Roderick S.,Palovich, Michael R.,Widdowson, Katherine L.,Werner, Michelle L.,Burman, Miriam,Foley, James J.,Schmidt, Dulcie B.,Sarau, Henry M.,Rogers, Martin,Salyers, Kevin L.,Gorycki, Peter D.,Roethke, Theresa J.,Stelman, Gary J.,Azzarano, Leonard M.,Ward, Keith W.,Busch-Petersen, Jakob
, p. 1713 - 1717 (2007/10/03)
N,N′-diarylsquaramides were prepared and evaluated as antagonists of CXCR2. The compounds were found to be potent and selective antagonists of CXCR2. Significant differences in SAR was observed relative to the previously described N,N′-diarylurea series. As was the case in the N,N′-diarylurea series, placing sulfonamide substituent adjacent to the acidic phenol significantly reduced the clearance in rat pharmacokinetic studies.
3-aminobenzoylphenylureas useful for controlling parasites and insects that attack domestic animals and livestock
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, (2008/06/13)
Novel compounds of formula I STR1 wherein each of R1, R2, R3, R7, R8 and R9, independently of the others, is H or halogen, R4 is H, R10 CO-- or R11 NHCO-- w
Use of 2,6-Dichlorobenzonitrile (Dichlobenil) as Starting Material for Synthesis of Herbicides, Derivatives of Benzoic Acid.
Romanowski,Wituch-Zapalowska,Eckstein
, p. 26 - 31,27, 28, 30 (2007/10/06)
Results of an investigation are presented in which S//N reactions of dichlobenil and its transformation products were investigated using as nucleophilic agents for chlorine exchange: sodium methanolate and ethanolate, as well as aniline and its derivatives. It has been shown that the ability to enter the reaction of mono- or disubstitution is dependent on the kind of derivative of 2,6-dichloro-3-nitrobenzoic acid, as well as on conditions of reactions. In the manner described above, dichlobenil has been transformed into valuable herbicide, dicamba, i. e. 3,6-dichloro-2-methoxybenzoic acid. A mixture of isomeric acids has been obtained, their herbicide activity having the same range.
