151765-33-2

Upstream product

• 151765-27-4 5-acetamido-1-C-acetoxymethyl-2,3,4,-tri-O-acetylcyclopentane-1,2,3,4-tetraol 
• 93173-26-3 2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl isothiocyanate 
• 151765-28-5 5-amino-1-C-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol 

Downstream Products

• 157009-54-6 (3aS,4S,5S,6R,6aR)-4-Hydroxymethyl-2-[(Z)-(2S,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-ylimino]-hexahydro-cyclopentaoxazole-4,5,6-triol 
• 157009-54-6 (3aS,4S,5S,6R,6aR)-4-Hydroxymethyl-2-((2S,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-ylamino)-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol 

Relevant academic research and scientific papers

Total Synthesis and Trehalase-Inhibitory Activity of Trehalostatin and Its Diastereoisomer

Complete synthesis of both diastereoisomeric structures, initially proposed for the trehalase inhibitor trehalostatin, and their biological assay have been carried out.The synthetic compounds were found to lack an inhibitory activity against trehalase, suggesting that the inhibitor would possess convincingly its 4'-epimeric structure later assigned for trehazolin.

Total Synthesis of the Trehalase Inhibitors Trehalostatin and Trehazolin, and of Their Diastereoisomers. Final Structural Confirmation of the Inhibitor

Potent trehalase inhibitors 1-4 have been synthesized, thereby establishing both the structure and the absolute configuration of the known inhibitor trehazolin 2.Compound 1, previously proposed as the structure of trehalostatin, and its diastereoisomer 3,