Total Synthesis and Trehalase-Inhibitory Activity of Trehalostatin and Its Diastereoisomer

Article abstract of DOI:10.1246/cl.1993.971

Complete synthesis of both diastereoisomeric structures, initially proposed for the trehalase inhibitor trehalostatin, and their biological assay have been carried out.The synthetic compounds were found to lack an inhibitory activity against trehalase, suggesting that the inhibitor would possess convincingly its 4'-epimeric structure later assigned for trehazolin.