1518-59-8

Usage

Uses

Used in Pharmaceutical Industry:
D-arabino-3-deoxyhexonic acid is used as an anti-inflammatory and antiviral agent for its potential therapeutic applications.
Used in Antibacterial Applications:
D-arabino-3-deoxyhexonic acid plays a crucial role in the biosynthesis of certain bacterial cell wall components, which may have implications in the development of new antibiotics.
Used in Biochemical Research:
D-arabino-3-deoxyhexonic acid is used as a significant chemical compound in biochemical research to study its diverse biological functions and potential therapeutic applications.

Upstream product

• 5517-48-6 3-deoxy-D-arabino-hexose 
• 50-99-7 D-glucose 
• 146-72-5 3-O-methyl-D-glucose 
• 124-41-4 sodium methylate 
• 7625-23-2 3,6-anhydro-D-glucose 
• 533-67-5 2-Deoxy-D-ribose 
• 143-33-9 sodium cyanide 
• 141-52-6 sodium ethanolate 
• 10230-17-8 O³-benzyl-D-glucose 
• 7732-18-5 water 
• 120581-02-4 O³-phosphono-D-glucose; barium salt 
• 6198-74-9 methyl (R)-3-deoxy-α-D-arabinohexopyranose 
• 3150-15-0 methyl 2,3-anhydro-4,6-O-benzilidene-α-D-mannopyranoside 
• 72904-78-0 methyl 3-deoxy-4,6-O-phenylmethylene-α-D-arabinohexopyranoside 

Downstream Products

• 533-67-5 2-Deoxy-D-ribose 

Relevant academic research and scientific papers

Alkoxycarbonyl elimination of 3-O-substituted glucose and fructose by heat treatment under neutral pH

3-O-Substituted reducing aldoses are commonly unstable under heat treatment at neutral and alkaline pH. In this study, to evaluate the decomposition products, nigerose (3-O-α-D-glucopyranosyl-D-glucose) and 3-O-methyl glucose were heated at 90 °C in 100 mM sodium phosphate buffer (pH 7.5). Decomposition via β-elimination was observed that formed a mixture of 3-deoxy-arabino-hexonic acid and 3-deoxy-ribo-hexonic acid; upon further acid treatment, it was converted to their γ-lactones. Similarly, turanose (3-O-α-D-glucopyranosyl-D-fructose), a ketose isomer of nigerose, decomposed more rapidly than nigerose under the same conditions, forming the same products. These findings indicate that 3-O-substituted reducing glucose and fructose decompose via the same 1,2-enediol intermediate. The alkoxycarbonyl elimination of 3-O-substituted reducing glucose and fructose occurs readily if an O-glycosidic bond is located on the carbon adjacent to the 1,2-enediol intermediate. Following these experiments, we proposed a kinetic model for the3- decomposition of nigerose and turanose by heat treatment under neutral pH conditions. The proposed model showed a good fit with the experimental data collected in this study. The rate constant of the decomposition for nigerose was (1.2 ± 0.1) × 10?4 s?1, whereas that for turanose [(2.6 ± 0.2) × 10?4 s?1] was about 2.2 times higher.

Production of aldoses

An aldose having n-1 carbon atoms is produced from an aldonic acid having n carbon atoms using hypochlorous acid or a hypochlorite in a high yield at low cost with safety, by treating the reaction mixture with a compound having reactivity with the hypochlorous acid or hypochlorite higher than that with the produced aldose.

Structure of the K95 antigen from Escherichia coli O75:K95:H5, a capsular polysaccharide containing furanosidic KDO-residues.

The structure of the K95 antigenic capsular polysaccharide (K95 antigen) of Escherichia coli O75:K95:H5 was elucidated by determination of the composition, 1H- and 13C-n.m.r. spectroscopy, periodate oxidation, and methylation analysis. The K95 polysaccharide, which contains furanosidic 3-deoxy-D-manno-2-octulosonic acid (KDOf) residues, consists of----3)-beta-D-Rib-(1----8)-KDOf-(2----repeating units, has a molecular weight of approximately 25,000 (approximately 65 repeating units), and is randomly O-acetylated (1 acetyl group per repeating unit at unknown positions).