15182-67-9

Usage

Structure

Tetrazole derivative with a five-membered ring containing four nitrogen atoms and one sulfur atom

Substituent

o-methoxyphenyl group attached to the tetrazole ring

Potential applications

a. Pharmaceutical industry
b. Anti-cancer agent
c. Antimicrobial properties
d. Antifungal properties

Research focus

Investigation of its biological properties and potential use in the development of novel drugs with therapeutic benefits

Unique features

Interesting structure and biological activities that make it an attractive target for further research and pharmaceutical development

InChI:InChI=1/C8H8N4OS/c1-13-7-5-3-2-4-6(7)12-8(14)9-10-11-12/h2-5H,1H3,(H,9,11,14)

Upstream product

• 66654-58-8 5-(o-anisylamino)-1,2,3,4-thiatriazole 
• 3288-04-8 1-isothiocyanato-2-methoxybenzene 
• 40207-02-1 4-(o-methoxyphenyl)thiosemicarbazide 
• 53662-51-4 (2-methoxy-phenyl)-dithiocarbamic acid ; compound with triethylamine 
• 854902-49-1 (2-methoxy-phenyl)-dithiocarbamic acid methyl ester 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 1061907-97-8 C₁₈H₁₈N₄O₄S 
• 1618101-13-5 5-[(3,5-dinitrobenzyl)sulfanyl]-1-(2-methoxyphenyl)-1H-tetrazole 
• 92044-03-6 1-(2-methoxy-phenyl)-4-morpholin-4-ylmethyl-1,4-dihydro-tetrazole-5-thione 

Relevant academic research and scientific papers

1-(2-Methoxyphenyl)-1,4-Dihydro-5H-Tetrazole-5-Thione and Its Complex with Cd(II): Molecular and Crystal Structures

Abstract: The molecular and crystal structures of 1-(2-methoxyphenyl)-1,4-dihydro-5H-tetrazole-5-thione (L) and its complex with cadmium(II) (II) are studied by X-ray diffraction analysis (CIF files CCDC nos.?1567109 (L) and 1547252 (II)). Free ligand L is nonplanar thione. The dihedral angle between the tetrazole and benzene cycles is 85.21(7)°. These cycles form centrosymmetric dimers in the crystal by two hydrogen bonds N–H···S. The dimers contain the central planar eight-membered ring {S=C–N–H···S=C–N–H···}. Complex II has a chain structure of the composition [(C8H7N4OS)2Cd]n. The coordination mode of the Сd(II) atom is a distorted tetrahedron consisting of two nitrogen atoms and two sulfur atoms of four ligands L. The 1D chains contain the eight-membered rings {←S=C–N–Cd ← S=C–N–Cd} in the boat conformation. Weak intermolecular hydrogen bonds C–H···N are observed between the adjacent 1D chains along the c axis in the crystal.

Synthesis of unsymmetrical sulfides derived from tetrazole-5-thiols

A series of unsymmetrical sulfides derived from I-substituted tetrazole-5-thiols was prepared by fusion of the corresponding 1-R-tetrazole-5-thiol sodium salt with 1-R′-5-halotetrazole. The structure was confirmed by 1H NMR and 13C NMR spectra. The target compounds were prepared in 50-80% yields.