151824-82-7Relevant articles and documents
Synthesis and potential anthelmintic activity of methyl-5-(4-salicyloyl-piperazin-1-yl)-benzimidazole-2-carbamates
Ravina,Sanchez-Alonso,Fueyo,Baltar,Bos,Iglesias,Sanmartin
, p. 689 - 694 (2007/10/02)
A series of methyl-5-(4-salicyloyl-piperazin-1-yl)-benzimidazole-2-carbamates (IX) has been prepared. 5-(4-salicyloyl-piperazin-1-yl)-2-nitro anilines (VII) have been synthesized starting from 5-piperazino-2-nitro anilines and salicyloyl chlorides. Catalytic reduction of VII with Pd/C, followed by treatment with 1,3-dicarbomethoxy-S-methyl isothiourea, yielded the corresponding carbamates (IX), the anthelmintic activity of which was studied. Compound IX(a) significantly reduced the numbers of preadults, adults and encysted T. spiralis larvae in experimental mice.