96103-52-5

Basic information

• Product Name: 2-Nitro-5-(1-piperazinyl)aniline
• Synonyms: 2-Nitro-5-(1-piperazinyl)aniline;2-nitro-5-(piperazin-1-yl)aniline
• CAS NO: 96103-52-5
• Molecular Formula: C₁₀H₁₄N₄O₂
• Molecular Weight: 222.24376
• Mol File: 96103-52-5.mol
• Article Data: 18

Chemical Properties

• Melting Point: 170 °C
• Boiling Point: 468.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.293±0.06 g/cm3(Predicted)
• PKA: 8?+-.0.10(Predicted)
• CAS DataBase Reference: 2-Nitro-5-(1-piperazinyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Nitro-5-(1-piperazinyl)aniline(96103-52-5)
• EPA Substance Registry System: 2-Nitro-5-(1-piperazinyl)aniline(96103-52-5)

Safety Data

• Hazardous Substances Data: 96103-52-5(Hazardous Substances Data)

Usage

General Description

2-Nitro-5-(1-piperazinyl)aniline is a chemical compound that is commonly used in the pharmaceutical industry, particularly in the synthesis of various drugs and medications. It is a nitroaromatic compound that contains a piperazine moiety, making it a valuable building block for the development of new pharmaceutical compounds. The nitro group on the aromatic ring is known for its ability to undergo various chemical reactions, making it a versatile precursor for the synthesis of a wide range of chemical compounds. The presence of the piperazine group also imparts unique properties to the molecule, allowing it to be used in the development of drugs targeted towards specific biological pathways or receptors. Overall, 2-Nitro-5-(1-piperazinyl)aniline is an important chemical compound in the pharmaceutical industry, playing a crucial role in the synthesis and development of new drugs and medications.

Upstream product

• 193902-98-6 4-(3-amino-4-nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 1635-61-6 5-chloro-2-nitroaniline 
• 110-85-0 piperazine 
• 29178-59-4 4-(4-acetylaminophenoxy)-2-amino-nitrobenzene 
• 2369-11-1 5-fluoro-2-nitroaniline 

Downstream Products

• 98526-49-9 [4-(3-Amino-4-nitro-phenyl)-piperazin-1-yl]-pyrazin-2-yl-methanone 
• 98526-47-7 [4-(3-Amino-4-nitro-phenyl)-piperazin-1-yl]-(1-hydroxy-naphthalen-2-yl)-methanone 
• 54997-96-5 4-(3-amino-4-nitro-phenyl)-piperazine-1-carboxylic acid diethylamide 
• 1339046-72-8 4-(3-amino-4-nitro-phenyl)-piperazine-1-carboxylic acid dimethylamide 
• 1339046-74-0 4-[2-(4-amino-3-nitro-phenyl)-1H-benzoimidazol-5-yl]-piperazine-1-carboxylic acid dimethylamide 
• 1339046-76-2 4-[2-(3,4-diamino-phenyl)-1H-benzoimidazol-5-yl]-piperazine-1-carboxylic acid dimethylamide 
• 668432-44-8 4-amino-5-fluoro-3-(6-piperazin-1-yl-1H-benzimidazol-2-yl)quinolin-2(1H)-one 
• 129244-60-6 2,6-Di-tert-butyl-4-[2-(5-piperazin-1-yl-1H-benzoimidazol-2-yl)-ethyl]-phenol 
• 129244-57-1 2,6-Di-tert-butyl-4-(5-piperazin-1-yl-1H-benzoimidazol-2-ylmethyl)-phenol 
• 96103-54-7 1-(4-amino-3-nitrobenzoyl)-4-(3-amino-4-nitrophenyl)piperazine 
• 96103-55-8 1-(3,4-diaminobenzoyl)-4-(3,4-diaminophenyl)piperazine 
• 103248-81-3 1-(7-chloroquinolin-4-yl)-4-(3,4-diaminophenyl)piperazine 
• 98526-65-9 C₂₈H₃₄N₈O₇ 
• 98526-64-8 C₂₅H₂₈N₈O₇ 

Relevant articles and documents

Pyrrole BET degradation agent and application thereof

The invention discloses a pyrrole BET degradation agent and application thereof, and belongs to the technical field of biological medicine. The BET protein degradation agent with a brand new parent nucleus structure is provided by adopting a PROTAC technology and comprises a protein target head A, a linker B and an E3 ubiquitination ligase ligand C. The BET protein degradation agent has excellent protein inhibition activity and anti-tumor cell proliferation activity, and compared with an original protein target head compound, the cell activity is greatly improved; and in addition, the preparation method is short in route, and raw materials are cheap and easy to obtain.

NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE

Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

N-aryl-2-aminobenzimidazoles: Novel, efficacious, antimalarial lead compounds

From the phenotypic screening of the AstraZeneca corporate compound collection, N-aryl-2-aminobenzimidazoles have emerged as novel hits against the asexual blood stage of Plasmodium falciparum (Pf). Medicinal chemistry optimization of the potency against Pf and ADME properties resulted in the identification of 12 as a lead molecule. Compound 12 was efficacious in the P. berghei (Pb) model of malaria. This compound displayed an excellent pharmacokinetic profile with a long half-life (19 h) in rat blood. This profile led to an extended survival of animals for over 30 days following a dose of 50 mg/kg in the Pb malaria model. Compound 12 retains its potency against a panel of Pf isolates with known mechanisms of resistance. The fast killing observed in the in vitro parasite reduction ratio (PRR) assay coupled with the extended survival highlights the promise of this novel chemical class for the treatment of malaria.