151864-73-2

Upstream product

• 50-01-1 guanidine hydrochloride 
• 151864-82-3 Ethyl 4-(4-hydroxy-3-oxobutyl)benzoate 
• 151864-81-2 ethyl 4-(3-oxopropyl)benzoate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 

Downstream Products

• 1040392-48-0 C₂₁H₂₂N₆O₅ 
• 1040392-49-1 C₂₅H₃₀N₆O₅ 
• 1040392-47-9 C₂₅H₃₀N₆O₅ 
• 134373-07-2 Diethyl N-<4-<2-(2,4-diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamate 
• 149010-53-7 4-<2-(2,4-Diaminopyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid 

Relevant academic research and scientific papers

A one-step ring transformation/ring annulation approach to pyrrolo[2,3-d]pyrimidines. A new synthesis of the potent DHFR inhibitor TNP-351

Condensation of amidines with 2-amino-3-cyanofurans gives 2-substituted-4-aminopyrrolo[2,3-d]pyrimidines by a ring-opening, ring-recyclization sequence of reactions through which the starting furan 2-amino nitrogen becomes the pyrrole nitrogen of the final product and one of the amidine nitrogens becomes N-1 of the fused pyrimidine ring. 2,4-Diamino-5-[2-(4-carbethoxyphenyl)ethyl]pyrrolo[2,3-d]pyrimidine, a key intermediate in the synthesis of the DHFR inhibitor TNP-351, has been prepared in one step by reaction of ethyl 4-[2-(2-amino-3-cyanofuran-4-yl)ethyl]benzoate with guanidine.

NEW CLASSICAL ANTIFOLATES

The present invention is directed to antifolate compounds having the structure of formula (I). wherein: X is CHR9 or NR9; Y1, Y2, and Y3 independently are O or S; V1 and V2 independently are O, S, or NZ; Z is H, optionally substituted alkyl, optionally su

Process for the preparation of pyrrolo[2,3-d]pyrimidines

5-Substituted pyrrolo[2,3-d]pyrimidines are prepared from a nucleophile of the formula R2 -C(=NH)NH2 and a 2-amino-5-substituted-furan carrying a cyano or carboxy group in the 4-position. A typical example is the preparation of ethyl