151915-04-7Relevant articles and documents
Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity
Bellevue III, Frank H.,Boahbedason, Michelle,Wu, Ronghui,Woster, Patrick M.,Casero Jr., Robert A.,Rattendi, Donna,Lane, Schennella,Bacchi, Cyrus J.
, p. 2765 - 2770 (2007/10/03)
A series of symmetrically or unsymmetrically alkyl-substituted polyamine analogues were synthesized containing either a 3-3-3 or 3-7-3 polyamine backbone. These analogues were evaluated in vitro as antitumor agents in the NCI H157 and NCI H82 lung carcinoma cell lines, and as antitrypanosomal agents against four strains of Trypanosoma brucei brucei or Trypanosoma brucei rhodesiense. The resulting biological data suggest that it is possible to specifically target tumor cells or parasitic organisms with alkylpolyamine analogues based on structure.
Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents
Saab,West,Bieszk,Preuss,Mank,Casero Jr.,Woster
, p. 2998 - 3004 (2007/10/02)
Spermidine/spermine-N1-acetyltranferase (SSAT), the rate-limiting step in polyamine catabolism, is critical for the interconversion and modulation of cellular polyamines. Inhibitor-initiated induction of this enzyme also appears to correlate wi