152-43-2

Usage

Uses

Used in Hormone Replacement Therapy:
Quinestrol is used as a hormone replacement agent for addressing various symptoms and conditions related to estrogen deficiency, such as menopausal symptoms and osteoporosis prevention.
Used in Postpartum Lactation Suppression:
Quinestrol is used as an agent for suppressing lactation in postpartum women, although its application in this context is limited and requires further study.
Used in Contraceptive Therapy:
In combination with synthetic progestogens, Quinestrol is used as a contraceptive agent. However, additional research is needed to fully understand its effectiveness and safety in this application.
Used in Pharmaceutical Industry:
Quinestrol is used as an isoleucyl-tRNA synthetase inhibitor, which has potential applications in the development of new drugs targeting specific enzymes.
Used in Antimicrobial Applications:
Quinestrol has antibacterial and antimycoplasmal properties, making it useful in the development of treatments for various bacterial and mycoplasma infections.

references

[1]. baumgardner sb, condrea h, daane ta, et al. replacement estrogen therapy for menopausal vasomotor flushes. comparison of quinestrol and conjugated estrogens. obstet gynecol. 1978 apr;51(4):445-52.[2]. skouby, s.o. criteria for the selection of an optimal estrogen replacement. gynecological endocrinology 15, 60-67 (2001).[3]. li j, chen f, li c,et al. quinestrol induces spermatogenic apoptosis in vivo via increasing pro-apoptotic proteins in adult male mice. tissue cell. 2014 oct;46(5):318-25.[4]. li j, chen f, chen y, et al. mitochondrial- and fas-l-mediated pathways involved in quinestrol induced spermatogenic apoptosis in adult rat testes. toxicol mech methods. 2014 dec;24(9):609-15.

InChI:InChI=1/C25H32O2/c1-3-25(26)15-13-23-22-10-8-17-16-19(27-18-6-4-5-7-18)9-11-20(17)21(22)12-14-24(23,25)2/h1,9,11,16,18,21-23,26H,4-8,10,12-15H2,2H3/t21-,22-,23+,24+,25+/m1/s1

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Crystal structure of Quinestrol (cas 152-43-2) hemiethanolate09/30/2019

The X-ray crystal structure of the synthetic sex steroid quinestrol (3-O-cyclopentyl-17α-ethynylestradiol) as crystallized from ethanolic solution is determined. The asymmetric unit contains two steroid and one ethanol molecules. The conformation of the two steroid molecules differs in the orie...detailed

Development and validation of a HPLC method for determination of levonorgestrel and Quinestrol (cas 152-43-2) in rat plasma09/29/2019

Levonorgestrel and quinestrol, commonly known as EP‐1, has long been used in the control of wild rodents. Up to the present time, however, no method for simultaneous quantification of levonorgestrel and quinestrol in rat plasma has been reported. In the present study, a sensitive reverse‐phase...detailed

Effects of Quinestrol (cas 152-43-2) and levonorgestrel on prolactin serum concentration in lactating Mongolian gerbils (Meriones unguiculatus) and reproductive parameters of their offspring09/28/2019

The effects of the two sterilants, quinestrol (QE) and levonorgestrel (LNG) on serum prolactin (PRL) level in lactating Mongolian gerbils and reproductive parameters of their offspring were examined in the study. Both sterilants increased the serum PRL level in lactating gerbils. The body weight...detailed

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