152-43-2

Basic information

• Product Name: Quinestrol
• Synonyms: 17-alpha-ethinylestradiol3-cyclopentylether;3-(cyclopentyloxy)-(17-alpha)-19-norpregna-5(10)-trien-20-yn-17-ol;3-(cyclopentyloxy)-19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yn-17-ol;5(10)-trien-20-yn-17-ol,3-(cyclopentyloxy)-19-nor-17-alpha-pregna-3;eecpe;eston;estradiol-17-beta3-cyclopentylether;estrovis
• CAS NO: 152-43-2
• Molecular Formula: C₂₅H₃₂O₂
• Molecular Weight: 364.52
• EINECS: 205-803-1
• Product Categories: BACTROBAN
• Mol File: 152-43-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 107-108°
• Boiling Point: 435.69°C (rough estimate)
• Flash Point: 218.8 °C
• Appearance: /
• Density: 1.0693 (rough estimate)
• Vapor Pressure: 6.43E-11mmHg at 25°C
• Refractive Index: 1.4480 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 13.10±0.40(Predicted)
• Merck: 14,8055
• CAS DataBase Reference: Quinestrol(CAS DataBase Reference)
• NIST Chemistry Reference: Quinestrol(152-43-2)
• EPA Substance Registry System: Quinestrol(152-43-2)

Safety Data

• Hazard Codes: T
• Statements: 45-61-20/21/22-46
• Safety Statements: 53-22-36/37/39-45
• WGK Germany: 3
• RTECS: RC8948000
• Hazardous Substances Data: 152-43-2(Hazardous Substances Data)

Usage

Description

Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy. It is a 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, it is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol. Quinestrol has found limited use in suppressing lactation in postpartum women and, in combination with synthetic progestogens, as contraceptive therapy, although additional studies are needed for both applications.

Uses

Different sources of media describe the Uses of 152-43-2 differently. You can refer to the following data:
1. antibacterial, antimycoplasmal, isoleucyl-tRNA synthetase inhibitor
2. Quinestrol is an estrogen-like compound.

Brand name

Estrovis (Parke-Davis).

references

[1]. baumgardner sb, condrea h, daane ta, et al. replacement estrogen therapy for menopausal vasomotor flushes. comparison of quinestrol and conjugated estrogens. obstet gynecol. 1978 apr;51(4):445-52.[2]. skouby, s.o. criteria for the selection of an optimal estrogen replacement. gynecological endocrinology 15, 60-67 (2001).[3]. li j, chen f, li c,et al. quinestrol induces spermatogenic apoptosis in vivo via increasing pro-apoptotic proteins in adult male mice. tissue cell. 2014 oct;46(5):318-25.[4]. li j, chen f, chen y, et al. mitochondrial- and fas-l-mediated pathways involved in quinestrol induced spermatogenic apoptosis in adult rat testes. toxicol mech methods. 2014 dec;24(9):609-15.

InChI:InChI=1/C25H32O2/c1-3-25(26)15-13-23-22-10-8-17-16-19(27-18-6-4-5-7-18)9-11-20(17)21(22)12-14-24(23,25)2/h1,9,11,16,18,21-23,26H,4-8,10,12-15H2,2H3/t21-,22-,23+,24+,25+/m1/s1

Upstream product

• 95282-98-7 19-acetoxyandrosta-1,4-diene-3,17-dione 
• 1852-81-9 estrone 3-cyclopentyl ether 
• 1066-54-2 trimethylsilylacetylene 
• 510-64-5 19-hydroxy-4-androstene-3,17-dione 
• 96-41-3 Cyclopentanol 
• 100271-25-8 3,3-ethanediyldioxy-5,6α-epoxy-19-nor-5α,17βH-pregn-20-yn-17-ol 
• 124263-27-0 3,3-ethanediyldioxy-5,10-epoxy-19-nor-5β,17βH-pregn-20-yn-17-ol 

Related news

Crystal structure of Quinestrol (cas 152-43-2) hemiethanolate09/30/2019

The X-ray crystal structure of the synthetic sex steroid quinestrol (3-O-cyclopentyl-17α-ethynylestradiol) as crystallized from ethanolic solution is determined. The asymmetric unit contains two steroid and one ethanol molecules. The conformation of the two steroid molecules differs in the orie...detailed

Development and validation of a HPLC method for determination of levonorgestrel and Quinestrol (cas 152-43-2) in rat plasma09/29/2019

Levonorgestrel and quinestrol, commonly known as EP‐1, has long been used in the control of wild rodents. Up to the present time, however, no method for simultaneous quantification of levonorgestrel and quinestrol in rat plasma has been reported. In the present study, a sensitive reverse‐phase...detailed

Effects of Quinestrol (cas 152-43-2) and levonorgestrel on prolactin serum concentration in lactating Mongolian gerbils (Meriones unguiculatus) and reproductive parameters of their offspring09/28/2019

The effects of the two sterilants, quinestrol (QE) and levonorgestrel (LNG) on serum prolactin (PRL) level in lactating Mongolian gerbils and reproductive parameters of their offspring were examined in the study. Both sterilants increased the serum PRL level in lactating gerbils. The body weight...detailed

Relevant articles and documents

Eco-friendly synthesis of 3-etherified estrones

The conventional etherification uses toxic or hardly degradable alkylating agents. An eco-friendly tandem etherification/aromatization is presented to prepare estrone 3-secondary ethers from easily available dienone 1. Three marketed 3-etherified estrogen drugs were synthesized with the method from commercial available starting material.