54589-53-6

Upstream product

• 50-00-0 formaldehyd 
• 591-50-4 iodobenzene 
• 18282-51-4 4-iodo-benzyl alcohol 
• 10026-13-8 phosphorus pentachloride 
• 873-75-6 4-bromobenzenemethanol 
• 876-08-4 p-(chloromethyl)benzoyl chloride 
• 100-44-7 benzyl chloride 
• 624-31-7 4-tolyl iodide 
• 19028-26-3 4-dichloroiodanyl-toluene 

Downstream Products

• 60599-65-7 phosphoric acid tris-(4-iodo-benzyl ester) 
• 51628-12-7 4-iodophenylacetonitrile 
• 56441-99-7 ethyl 4-(4-iodobenzyloxy)benzoate 
• 619-58-9 4-iodobenzoic acid 
• 887139-20-0 {4-[1-(4-iodo-benzyl)-5-oxo-1,5-dihydro-[1,2,4]triazol-4-yl]-benzyl}-methyl-carbamic acid tert-butyl ester 
• 918540-55-3 4-(4-iodophenyl)-2-butanone 
• 411221-85-7 2-(4-iodobenzyl)-isoindoline-1,3-dione 
• 1206189-72-1 2-(4-iodophenyl)-6-methoxy-1,3-benzothiazole 
• 1417915-62-8 (Z)-2-(5-((6-((4-iodobenzyl)oxy)naphthalen-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid 
• 1417915-85-5 C₁₈H₁₃IO₂ 
• 1192590-80-9 (R)-N-4'-(iodo)benzyl 2-acetamido-3-methoxypropionamide 
• 1197982-72-1 (R)-N-4-(3-methoxyprop-1-ynyl)benzyl 2-acetamido-3-methoxypropionamide 
• 1197982-73-2 (R)-N-4-(3-methoxypropyl)benzyl 2-acetamido-3-methoxypropionamide 
• 1192590-72-9 (R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-hydroxypropionamide 

Relevant academic research and scientific papers

1-methyl-3-(4-diacetoxyl iodobenzene methyl) imidazole chlorine salt as well as preparation and application thereof

The invention discloses 1-methyl-3-(4-diacetoxyl iodobenzene methyl) imidazole chlorine salt as well as preparation and application thereof. The structure of the 1-methyl-3-(4-diacetoxyl iodobenzene methyl) imidazole chlorine salt is shown in the specification. The invention provides application of the 1-methyl-3-(4-diacetoxyl iodobenzene methyl) imidazole chlorine salt as a gold leaching agent. The application comprises the following steps: putting a sample with a noble metal into the 1-methyl-3-(4-diacetoxyl iodobenzene methyl) imidazole chlorine salt, and performing sufficient stirring so as to leach the noble metal. The 1-methyl-3-(4-diacetoxyl iodobenzene methyl) imidazole chlorine salt which is disclosed by the invention has good capabilities of oxidation and metal coordination, canbe used as the gold leaching agent, breaks through the defect that a toxic gold leaching agent is used in the conventional metallurgical industry, and has the advantages of being efficient, green andenvironment-friendly and sustainable.

Halogenation through Deoxygenation of Alcohols and Aldehydes

An efficient reagent system, Ph3P/XCH2CH2X (X = Cl, Br, or I), was very effective for the deoxygenative halogenation (including fluorination) of alcohols (including tertiary alcohols) and aldehydes. The easily available 1,2-dihaloethanes were used as key reagents and halogen sources. The use of (EtO)3P instead of Ph3P could also realize deoxy-halogenation, allowing for a convenient purification process, as the byproduct (EtO)3Pa?O could be removed by aqueous washing. The mild reaction conditions, wide substrate scope, and wide availability of 1,2-dihaloethanes make this protocol attractive for the synthesis of halogenated compounds.

Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides

Current methods for functional group interconversion have, for the most part, relied on relatively strong driving forces which often require highly reactive reagents to generate irreversibly a desired product in high yield and selectivity. These approaches generally prevent the use of the same catalytic strategy to perform the reverse reaction. Here we describe a catalytic functional group metathesis approach to interconvert, under CO-free conditions, two synthetically important classes of electrophiles that are often employed in the preparation of pharmaceuticals and agrochemicals—aroyl chlorides (ArCOCl) and aryl iodides (ArI). Our reaction design relies on the implementation of a key reversible ligand C–P bond cleavage event, which enables a non-innocent, metathesis-active phosphine ligand to mediate a rapid aryl group transfer between the two different electrophiles. Beyond enabling a practical and safer approach to the interconversion of ArCOCl and ArI, this type of ligand non-innocence provides a blueprint for the development of a broad range of functional group metathesis reactions employing synthetically relevant aryl electrophiles.

Efficient iodination of aromatic compounds using potassium ferrate supported on montmorillonite

Potassium ferrate impregnated on montmorillonite is a mild, cheap, and non-toxic reagent for the iodination of phenols, including naphthol, aromatic amines, and heterocyclic substrates in fair to excellent yields by a simple isolation procedure.

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processi to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line pu fication.

Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent σ1receptor ligands

A series of N-(1-benzylpiperidin-4-yl)arylacetamides were synthesized and evaluated for their binding properties for σ1 and σ2 receptors. In agreement with previously reported σ1/σ2 receptor binding data for N-(1-benzylpiperidin-4-yl)phenylacetamide, all of the N-(1-benzylpiperidin-4-yl)arylacetamide compounds reported below displayed higher affinity for σ1 vs σ1 receptors. Replacement of the phenyl ring of the phenylacetamide moiety with a thiophene, naphthyl, or indole aromatic ring had no significant effect on the σ1 receptor affinity. Replacement of the phenyl ring with an imidazole or pyridyl aromatic ring resulted in a >60-fold loss in affinity for σ1 receptors and no significant binding affinity for σ2 receptors. Substitution on the aromatic ring of the benzyl group showed a similar or slightly decreased affinity for σ1 receptors. Substitution on the aromatic rings of both the phenylacetamide moiety and the benzyl group with a halogen resulted in a similar affinity for σ1 receptors and a significantly increased affinity for σ2 receptors. Comparative molecular field analysis revealed that electrostatic properties of the substituents in the phenylacetamide aromatic ring strongly influenced binding to σ1 receptors. Compounds 1, 10, 18, 22, 37, and 40 showed the highest selectivity for σ1 receptors with Ki (σ2) to Ki (σ1) ratios of 100, >92, >122, 77, 74, and 80, respectively. In agreement with previously reported results, the phenylacetamide analogues had no binding affinity for dopamine receptors (D2/D3).

Triazolylated teritiary amine compound or salt thereof

A triazolylated tertiary amine compound represented by general formula (I) or a salt thereof, having an aromatase inhibitory activity and being useful for preventing and treating breast cancer, mastopathy, endometriosis, prostatomergaly, etc., wherein A represents a single bond, lower alkylene or carbonyl; B represents lower alkyl, aryl, a 5- or 6-membered heterocyclic group, or a bicyclic fused heterocyclic group; D represents aryl, a 5- or 6-membered heterocyclic group, or a bicyclic fused heterocyclic group; and E represents 4H-1,2,4-triazolyl, 1H-1,2,4-triazolyl or 1H-1,2,3-triazolyl.