15207-88-2Relevant academic research and scientific papers
First bisphosphonate hydrogelators: Potential composers of biocompatible gels
Alanne, Aino-Liisa,Lahtinen, Manu,Loefman, Miika,Turhanen, Petri,Kolehmainen, Erkki,Vepsaelaeinen, Jouko,Sievaenen, Elina
, p. 6201 - 6212 (2013)
Recently, investigation of hydrogels has gained ever increasing attention mostly because of their biomedical and pharmaceutical properties, and novel hydrogelators are constantly studied to find functional applications. Bisphosphonates (BPs) are well-known compounds applicable in different fields but are mostly used in clinics as drugs for bone-related diseases. In this study, a novel class of BP-hydrogelators together with a BP-organogelator was found, and the gelating abilities of the compounds were studied. Several techniques to analyze the structure and the properties of the formed gels were used, including solid state 13C and 31P CPMAS and solution state NMR spectroscopy, IR spectroscopy, PXRD, thermoanalysis, as well as SEM. The Royal Society of Chemistry.
Methylenebisphosphonic acid derivatives
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, (2008/06/13)
Novel pharmacologically active methylenebisphosphonates having formula (I) wherein R1, R2, R3 and R4 independently are straight or branched, optionally unsaturated C1 -C10 -alkyl, optionally unsaturated C3 -C10 -cycloalkyl, aryl, aralkyl, silyl SiR3 or hydrogen, whereby in formula (I) at least one of the groups R1, R2, R3 or R4 is hydrogen and at least one of the groups is different from hydrogen, Q1 is hydrogen, hydroxyl, halogen, amino NH2, or OR', wherein R' is C1 -C4 -lower alkyl or acyl, Q2 is straight or branched, optionally unsaturated C1 -C10 -alkyl, -hydroxyalkyl or -aminoalkyl, whereby the oxygen may, as a substituent, contain one group or the nitrogen as a substituent may contain one or two groups, which are C1 -C4 -lower alkyl or acyl, or the two substituents of the nitrogen form together with the nitrogen atom a saturated, partly saturated or an aromatic heterocyclic ring, or Q2 is optionally substituted and optionally unsaturated C3 - C10 -cycloalkyl, which optionally is bound to the molecule over a straight or branched alkylene group containing 1-4 C-atoms, including the stereoisomers, such as the geometrical isomers and the optically active isomers, of the compounds, as well as the pharmacologically acceptable salts of these compounds. STR1
