152092-60-9Relevant academic research and scientific papers
Phosphinato(dialkylmethyl)phosphonates as pyrophosphate mimics: synthesis and squalene synthetase inhibitory activity of farnesyl phosphinato(dialkylmethyl)phosphonates
Prashad, M,Tomesch, JC,Wareing, JR,Scallen, T
, p. 527 - 531 (1993)
The synthesis and squalene synthetase inhibitory activity of farnesyl phosphinato(dialkylmethyl)phosphonates has been described.The phosphinato(dimethylmethyl)phosphonate group provided a suitable mimic of pyrophosphate. squalene synthetase / phosphinato(dialkylmethyl)phosphonate / pyrophosphate mimics / cholesterol biosynthesis pathway / enzyme inhibitors
