Phosphinato(dialkylmethyl)phosphonates as pyrophosphate mimics: synthesis and squalene synthetase inhibitory activity of farnesyl phosphinato(dialkylmethyl)phosphonates

DOI: 10.1016/0223-5234(93)90022-7

Source and publish data:

European Journal of Medicinal Chemistry p. 527 - 531 (1993)

Update date:2022-08-04

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Authors:

Prashad, M

Tomesch, JC

Wareing, JR

Scallen, T

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Article abstract of DOI:10.1016/0223-5234(93)90022-7

The synthesis and squalene synthetase inhibitory activity of farnesyl phosphinato(dialkylmethyl)phosphonates has been described.The phosphinato(dimethylmethyl)phosphonate group provided a suitable mimic of pyrophosphate. squalene synthetase / phosphinato(dialkylmethyl)phosphonate / pyrophosphate mimics / cholesterol biosynthesis pathway / enzyme inhibitors

Full text of DOI:10.1016/0223-5234(93)90022-7

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