Phosphinato(dialkylmethyl)phosphonates as pyrophosphate mimics: synthesis and squalene synthetase inhibitory activity of farnesyl phosphinato(dialkylmethyl)phosphonates

DOI: 10.1016/0223-5234(93)90022-7

Source and publish data:

European Journal of Medicinal Chemistry p. 527 - 531 (1993)

Update date:2022-08-04

Topics:

Authors:

Prashad, M

Tomesch, JC

Wareing, JR

Scallen, T

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0223-5234(93)90022-7

The synthesis and squalene synthetase inhibitory activity of farnesyl phosphinato(dialkylmethyl)phosphonates has been described.The phosphinato(dimethylmethyl)phosphonate group provided a suitable mimic of pyrophosphate. squalene synthetase / phosphinato(dialkylmethyl)phosphonate / pyrophosphate mimics / cholesterol biosynthesis pathway / enzyme inhibitors

Full text of DOI:10.1016/0223-5234(93)90022-7

Products guided by the article

Product name:diethyl 1-<ethoxyphosphinoyl>-1-methylethylphosphonate

Cas No:152092-60-9

R&D Labs maybe for 152092-60-9

HOST COUNTRY LIMITED

Contact:+852 83038667

Address:Room 1502, 15th Floor, SPA Centre,53-55 Lockhart Road, Wanchai, Hong Kong
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

website:http://www.shydtec.com

Contact:86-21-57721279

Address:Science and Technology Park, Songjiang District, Shanghai, China
Shanghai Minstar Chemical Co., Ltd

website:http://www.minstargroup.com

Contact:86-21-18019205509

Address:BUILDING 8, NO.1098, CHUANSHA ROAD, SHANGHAI, CHINA
Shanghai Taibao Pharmaceutical Technology Co., Ltd(expird)

Contact:021-52217366

Address:shanghai
CHEMINN LTD.

website:http://www.cheminn.com/

Contact:86-531-67875205

Address:No.9-2,South of Shanda Road, Jinan ,China

Relevant to this article

Electrochemical oxidation of 2,5-diethoxy-4-morpholinoaniline in aqueous solutions

Doi:10.1016/j.electacta.2013.09.063
(2013)
Doi:10.1016/S0040-4039(01)99062-8
(1968)
Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts

Doi:10.1016/j.phytochem.2004.08.026
(2004)
Hydroxylated polyfunctionalized benzo[c]coumarins by an organocatalyzed tandem 1,4-conjugate addition, decarboxylation and aromatization reaction

Doi:10.1055/s-0033-1339895
(2013)
A convenient synthesis of 9-hydroxy-3,4,5,6-tetrahydro-1H-azepino [5,4,3-cd] indole from 7-methoxyindole

Doi:10.1080/00397919308013802
(1993)
Synthesis and spectral characterization of some new thiazolyl-pyrazolines bearing 1,2,4-triazole moiety

Doi:10.1080/10426507.2010.497519
(2011)

Article Doi