European Journal of Medicinal Chemistry p. 527 - 531 (1993)
Update date:2022-08-04
Topics:
Prashad, M
Tomesch, JC
Wareing, JR
Scallen, T
The synthesis and squalene synthetase inhibitory activity of farnesyl phosphinato(dialkylmethyl)phosphonates has been described.The phosphinato(dimethylmethyl)phosphonate group provided a suitable mimic of pyrophosphate. squalene synthetase / phosphinato(dialkylmethyl)phosphonate / pyrophosphate mimics / cholesterol biosynthesis pathway / enzyme inhibitors
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