15210-04-5Relevant academic research and scientific papers
TiCl4-n-Bu3N-mediated cascade annulation of ketones with α-ketoesters: A facile synthesis of highly substituted fused γ-alkylidene-butenolides
Palange, Megha N.,Gonnade, Rajesh G.,Kontham, Ravindar
, p. 5749 - 5759 (2019/06/18)
A facile protocol for the synthesis of highly substituted fused γ-alkylidene butenolides using direct annulation of ketones with α-ketoesters, which proceeds through TiCl4-n-Bu3N mediated aldol addition followed by an intramolecular
Aldol-type reaction of α-halo ketones with α-ketocarboxylates mediated by SmI2 or SmI3: Facile synthesis of α-hydroxy-γ-ketocarboxylates
Arime,Kato,Komadate,Saegusa,Mori
, p. 3315 - 3319 (2007/10/02)
The title reaction smoothly proceeds at room temperature to give α-hydroxy-γ-keto esters 3 in good yields, probably via a mechanism involving samarium enolates formed in situ from α-halo ketones.
