1056477-06-5Relevant academic research and scientific papers
Metal-free protocol for the synthesis of α-bromo ketones from olefins using TsNBr2
Rajbongshi, Kamal Krishna,Hazarika, Debojit,Phukan, Prodeep
, p. 356 - 358 (2015)
TsNBr2 reacts readily with olefins to produce α-bromo ketones at room temperature. The synthesis was carried out by treating an olefin with TsNBr2 in acetone-water mixture in 30:1 ratio. Excellent yield of corresponding α-bromo ketone could be achieved within a short time.
Water-soluble poly(ε-caprolactone)-Paclitaxel prodrugs toward an efficient drug delivery system
Wang, Ji,Sun, Huanjiao,Li, Deshan,Yuan, Jie,Zhang, Xuefei,Tang, Haoyu
, p. 1136 - 1143 (2015)
In this paper, poly(ε-caprolactone)-graft-carboxylic acid (P(α-C2CL)) was prepared via a thio-bromo click reaction between mercaptosuccinic acid and poly(α-bromo-ε-caprolactone). It is readily soluble in aqueous solutions (pH 5.5-9.8) due to the presence
Synthesis of Antibacterial Glycosylated Polycaprolactones Bearing Imidazoliums with Reduced Hemolytic Activity
Xu, Yuan,Zhang, Kaixi,Reghu, Sheethal,Lin, Yichao,Chan-Park, Mary B.,Liu, Xue-Wei
, p. 949 - 958 (2019)
Most synthetic antimicrobial polymers are not biodegradable, thus limiting their potential for large-scale applications in personal care disinfection and environmental contaminations. Poly(?-caprolactone) (PCL) is known to be both biodegradable and biocom
Molecular modeling and biological evaluation of 2-N,N- dimethylaminecyclohexyl 1-N′,N′-dimethylcarbamate isomers and their methylsulfate salts as cholinesterases inhibitors
Bocca, Cleverson C.,Rittner, Roberto,H?ehr, Nelci F.,Pinheiro, Glaucia M.S.,Abiko, Layara A.,Basso, Ernani A.
, p. 194 - 199 (2010)
This work presents a detailed theoretical and experimental study on the inhibitory properties of 2-N,N-dimethylaminecyclohexyl 1-N′,N′- dimethylcarbamate isomers and their methylsulfate salts against the cholinesterases enzymes. The in vitro inhibition test performed by the Ellman's method showed that the salt form compounds were more active than the neutral ones in cholinesterases inhibition. The trans salt showed good selectivity towards the inhibition of erythrocyte cholinesterase with a maximum limit around 90% and 55% for the plasma cholinesterase inhibition. Molecular modeling, docking and experimental results performed in this study showed to be important initial steps toward the development of a novel pharmaceuticals in the fight against Alzheimer's disease.
Application of poly(vinylphenyltrimethylammonium tribromide) resin as an efficient polymeric brominating agent in the α-bromination and α-bromoacetalization of acetophenones
Han, Bingbing,Zheng, Zubiao,Zheng, Dongcheng,Zhang, Lei,Cui, Peng,Shi, Jianjun,Li, Changjiang
, p. 2512 - 2520 (2019)
The applications of a new supported tribromide reagent based on poly(vinylbenzyltrimethylammonium hydroxide) resin (Amberlite 717) were reported. This supported tribromide resin was used directly in α-bromination and α-bromoacetalization of acetophenones without any other catalyst under mild conditions. The effects of solvents and the amount of the supported tribromide resin on the reactions were investigated. Under the optimal conditions, most of α-bromo and α-bromoacetal of acetophenones were selectively obtained in excellent yields.
Protonation of silylenol ether via excited state proton transfer catalysis
Das, Anjan,Banerjee, Tanmay,Hanson, Kenneth
, p. 1350 - 1353 (2016)
We demonstrate the photocatalytic protonation of a silylenol ether using 7-bromo-2-naphthol as an ESPT catalyst with phenol as the sacrificial proton source. Greater than 95% conversion is achieved with 1 mol% catalyst. The reaction cycle is dependent on the significantly increased acidity of the catalyst in the excited state as well as the long lifetime for the triplet excited state of 7-bromo-2-naphthol. The reaction does not occur in the absence of light (367 nm) and can readily be controlled by light intensity modulation. We also demonstrate that a 72% reaction yield can be obtained with unsubstituted naphthol as the catalyst by coupling triplet energy transfer, via a visible light absorbing (445 nm) sensitizer, into the catalytic cycle. These results open the door to an entirely new class of sensitized photocatalytic reactions that harness the excited state acidity of ESPT dyes.
1,3-Dibromo-5,5-dimethylhydantoin (DBH) mediated one-pot syntheses of α-bromo/amino ketones from alkenes in water
Xu, Senhan,Wu, Ping,Zhang, Wei
, p. 11389 - 11395 (2016)
α-Bromo ketones are versatile intermediates of high practical utility. Traditional approaches to these compounds are restricted to a relatively hazardous/complex reagent combination, a long reaction time, the use of non-environmentally friendly solvents, or a limited substrate scope. Herein, we describe the development of a new methodology for the preparation of α-bromo ketones from alkenes using 1,3-dibromo-5,5-dimethylhydantoin (DBH) as a bromine source and an oxidant simultaneously. This easy to carry out two-step one-pot protocol proceeds in water and provides high yield of a great variety of α-bromo ketones. Addition of an amine to the intermediate α-bromo ketone further enables the preparation of α-amino ketones in a one-pot sequence.
On the4 JHH long-range coupling in 2-bromocyclohexanone: Conformational insights
Coelho, Jakelyne V.,Freitas, Matheus P.,Tormena, Claudio F.,Rittner, Roberto
, p. 348 - 351 (2009)
2-Bromocyclohexanone is a model compound in which a 4J H2,H6 coupling constant is observed, whereas the corresponding 4-4H2,H4 is absent. The observed long-range coupling is not only a result of the known W-type
SYNTHESIS OF 4-IMIDAZOLIN-2-ONES
Zav'yalov, S. I.,Sitkareva, I. V.,Ezhova, G. I.,Dorofeeva, O. V.,Zavozin, A. G.,Rumyantseva, E. E.
, p. 1297 - 1299 (1990)
The reaction of α-bromoketones with CO(NH2)2 and AcONH4 in aqueous acetic acid gave substituted 4-imidazolin-2-ones.
Tuned Cationic Dendronized Polymer: Molecular Scavenger for Rheumatoid Arthritis Treatment
Peng, Bo,Liang, Huiyi,Li, Yuyan,Dong, Cong,Shen, Jun,Mao, Hai-Quan,Leong, Kam W.,Chen, Yongming,Liu, Lixin
, p. 4254 - 4258 (2019)
Cell-free deoxyribonucleic acid (cfDNA) released from either dead or damaged cells serves as a key autoantigen in rheumatoid arthritis (RA). They can be recognized by nucleic acid (NA) sensors such as the toll-like receptor (TLR), leading to activation of
