152152-17-5

Basic information

• Product Name: 3,4-DIFLUOROCINNAMIC ACID
• Synonyms: 3,4-Difluorocinnamicacid; 3-(3,4-Difluorophenyl)acrylic acid
• CAS NO: 152152-17-5
• Molecular Formula: C₉H₆F₂O₂
• Molecular Weight: 184.1438
• Mol File: 152152-17-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 281.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.379±0.06 g/cm3(Predicted)
• PKA: 4.27±0.10(Predicted)
• CAS DataBase Reference: 3,4-DIFLUOROCINNAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIFLUOROCINNAMIC ACID(152152-17-5)
• EPA Substance Registry System: 3,4-DIFLUOROCINNAMIC ACID(152152-17-5)

Safety Data

• Hazardous Substances Data: 152152-17-5(Hazardous Substances Data)

Upstream product

• 141-82-2 malonic acid 
• 34036-07-2 3,4 difluorobenzaldehyde 

Downstream Products

• 161712-77-2 5,6-difluoroindan-1-one 
• 161712-75-0 3-(3,4-difluorophenyl)-propanoic acid 
• 605658-32-0 3-chloro-5,6-difluorobenzo[b]thiophene-2-carbonyl chloride 
• 1279713-94-8 (S)-2-(3-chloro-5,6-difluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid 
• 1279713-81-3 (R)-2-(3-chloro-5,6-difluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid 
• 1393689-96-7 4-(2-bromovinyl)-1,2-difluorobenzene 
• 1224709-41-4 (E)-4-(2-bromovinyl)-1,2-difluorobenzene 
• 168285-28-7 5-(3,4-Difluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 803687-25-4 ethyl 3-(3,4-difluorophenyl)propanoate 
• 1352428-65-9 C₃₀H₃₄F₂N₄O₂ 
• 1043546-64-0 3,4-difluorocinnamoyl chloride 
• 31105-90-5 (L)-2-amino-3-(3,4-difluorophenyl)propanoic acid 

Relevant articles and documents

Dual Nickel/Ruthenium Strategy for Photoinduced Decarboxylative Cross-Coupling of α,β-Unsaturated Carboxylic Acids with Cycloketone Oxime Esters

Herein, a dual nickel/ruthenium strategy is developed for photoinduced decarboxylative cross-coupling between α,β-unsaturated carboxylic acids and cycloketone oxime esters. The reaction mechanism is distinct from previous photoinduced decarboxylation of α,β-unsaturated carboxylic acids. This reaction might proceed through a nickelacyclopropane intermediate. The C(sp2)-C(sp3) bond constructed by the aforementioned reaction provides an efficient approach to obtaining various cyanoalkyl alkenes, which are synthetically valuable organic skeletons in organic and medicinal chemistry, under mild reaction conditions. The protocol tolerates many critical functional groups and provides a route for the modification of complex organic molecules.

New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation

Two novel series of phenylacrylamide linked coumarins and sulfocoumarins (6a-p, 8a-i, and 14a-g) were synthesized and evaluated against four physiologically relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I, hCA II, hCA IX and hCA XII for their inhibitory action. All new compounds when screened for carbonic anhydrase inhibitory activity have shown selective inhibition towards the tumor associated isoforms hCA IX and XII over CA I and II, with inhibition constants in the submicromolar to low nanomolar range. Compound 6b and 14g exhibited significant inhibition with low nanomolar potency against hCA IX, whereas 6k was effective against hCA XII. Compounds 6b, 14g and 6k may be considered as lead molecules for future development of cancer therapeutics based on a novel mechanism of action.

Process for preparing cinnamic acids and alkyl esters thereof

A process for producing cinnamic acids and alkyl esters thereof, particularly, fluorinated cinnamic acids and alkyl esters thereof. The process comprises reacting the appropriate bromobenzene and acrylic acid ester in a palladium-catalyzed HECK reaction under JEFFREY conditions using a phase-transfer catalyst (PTC) and an organic base to produce the corresponding cinnamic acid ester, and then preferably hydrolyzing the resulting ester under appropriate basic conditions, e.g. in the presence of a hydroxide, and precipitating the corresponding cinnamic acid product.