152169-44-3

Upstream product

• 367-27-1 2,4-difluorophenol 
• 152169-43-2 2,4-difluorophenyl ethyl carbonate 
• 113512-57-5 2,4-difluoro-5-nitrophenol 

Downstream Products

• 152169-45-4 2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol 
• 152169-56-7 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-4H-1-benzopyran-4-one 
• 152835-71-7 6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one 
• 152835-78-4 ethyl 3,5-difluoro-6-(N-pivaloylamino)-2-(2-tetrahydropyranyloxy)benzoate 
• 152169-46-5 2,4-difluoro-5-pivaloylamino-3-trimethylsilyl-O-(2-tetrahydropyranyl)phenol 
• 152835-84-2 ethyl 3,5-difluoro-6-pivaloylamino-2-(2-tetrahydropyranyloxy)-4-trimethylsilylbenzoate 

Relevant academic research and scientific papers

Synthesis of an ethyl 6-amino-3,5-difluorosalicylate derivative by sequential regioselective directed ortho- metalation; a practical synthesis of 4',5-Diamino-3',6,8-trifluoroflavone, a potent antitumor agent

The multigram scale synthesis of 4',5-diamino-3'6,8-trifluoroflavone, a potent antitumor agent, is described in which regioselective introduction of a carbonyl group into the ortho-position to the amide group of 2-[2,4-difluoro-5-(pivaloylamino)phenyoxy]tetrahydropyran is achieved by using sequential direct ortho-metalations as the key step.

5-aminoflavone derivatives

5-Aminoflavone derivatives represented by the formula (I): STR1 wherein R1, R2, R3 and R4 are the same or different and represent hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, halogen-substi