152169-56-7

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-
• CAS NO: 152169-56-7
• Molecular Formula: C15H9F3N2O2
• Molecular Weight: 306.244
• Mol File: 152169-56-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-(152169-56-7)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-(152169-56-7)

Safety Data

• Hazardous Substances Data: 152169-56-7(Hazardous Substances Data)

Upstream product

• 152835-71-7 6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one 
• 152835-82-0 N-(2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4,6-difluoro-3-methoxymethoxy-phenyl)-2,2-dimethyl-propionamide 
• 152835-59-1 ethyl 3,5-difluoro-6-(N-ethoxycarbonyl-N-pivaloylamino)-2-methoxymethoxybenzoate 
• 152169-42-1 ethyl 3,5-difluoro-6-(N-ethoxycarbonylamino)-2-methoxymethoxybenzoate 
• 152169-41-0 ethyl 3,5-difluoro-6-(N-ethoxycarbonylamino)-2-hydroxybenzoate 
• 152169-36-3 ethyl 6-(N-ethoxycarbonylamino)-2-hydroxybenzoate 
• 146463-87-8 ethyl 2-(N-ethoxycarbonyl-N-pivaloyl)amino-6-(tetrahydropyran-2-yloxy)benzoate 
• 152835-84-2 ethyl 3,5-difluoro-6-pivaloylamino-2-(2-tetrahydropyranyloxy)-4-trimethylsilylbenzoate 
• 152169-46-5 2,4-difluoro-5-pivaloylamino-3-trimethylsilyl-O-(2-tetrahydropyranyl)phenol 
• 152169-45-4 2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol 
• 152169-44-3 2,4-difluoro-5-pivaloylaminophenol 
• 152169-43-2 2,4-difluorophenyl ethyl carbonate 
• 113512-57-5 2,4-difluoro-5-nitrophenol 
• 113512-71-3 2,4-difluoro-5-hydroxyaniline 

Downstream Products

• 152835-72-8 2-(4-Acetylamino-3-fluorophenyl)-5-amino-6,8-difluoro-4H-1-benzopyran-4-one 

Relevant articles and documents

Synthesis of an ethyl 6-amino-3,5-difluorosalicylate derivative by sequential regioselective directed ortho- metalation; a practical synthesis of 4',5-Diamino-3',6,8-trifluoroflavone, a potent antitumor agent

The multigram scale synthesis of 4',5-diamino-3'6,8-trifluoroflavone, a potent antitumor agent, is described in which regioselective introduction of a carbonyl group into the ortho-position to the amide group of 2-[2,4-difluoro-5-(pivaloylamino)phenyoxy]tetrahydropyran is achieved by using sequential direct ortho-metalations as the key step.

5-aminoflavone derivatives

5-Aminoflavone derivatives represented by the formula (I): STR1 wherein R1, R2, R3 and R4 are the same or different and represent hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, halogen-substi