152188-51-7Relevant academic research and scientific papers
Enhancement of Alkene Reactivity by a Trifluoromethyl group: Synthesis of Pyrrolidines via 1,3-Dipolar Cycloaddition
Begue, Jean-Pierre,Bonnet-Delpon, Daniele,Lequeux, Thierry
, p. 3279 - 3282 (1993)
Ethylenic compounds activated by a trifluoromethyl group undergo 1,3-dipolar cycloadditions with non-stabilized azomethine ylides to provide polysubstituted 3-trifluoromethyl-pyrrolidines in good yields, while non-fluorinated parent alkenes are in most ca
Bicyclic-Fused Heteroaryl or Aryl Compounds
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Paragraph 0803; 0804, (2015/10/28)
Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
[3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions
Grafton, Mark,Mansfield, Andrew C.,Fray, M. Jonathan
scheme or table, p. 1026 - 1029 (2010/04/02)
The [3+2] dipolar cycloaddition reactions of the unstabilised azomethine ylide precursor benzyl(methoxymethyl)(trimethylsilylmethyl)amine with 12 electron-deficient alkenes in the presence of catalytic trifluoroacetic acid are examined under continuous fl
AMINO-HETEROCYCLIC COMPOUNDS
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Page/Page column 28, (2009/02/11)
The invention provides PDE9-inhibiting compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R, R1, R2 and R3 are as defined herein. Pharmaceutical compositions containing the compounds of Formul
Synthesis and structure-activity relationships of 2-pyridones: II. 8- (fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents
Li, Qun,Wang, Weibo,Berst, Kristine B.,Claiborne, Akiyo,Hasvold, Lisa,Raye, Kathleen,Tufano, Michael,Nilius, Angela,Shen, Linus L.,Flamm, Robert,Alder, Jeff,Marsh, Kennan,Crowell, DeAnne,Chu, Daniel T.W.,Planner, Jacob J.
, p. 1953 - 1958 (2007/10/03)
The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, making them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted amines at the 8-position has been synthesized and their antibacterial activities and parmacokinetic properties are reported.
Synthesis and antibacterial activity of novel 7-(3-substituted-3 or 4- trifluoromethyl-1-pyrrolidinyl)-8-methoxyfluoroquinolones
Fukui, Hideto,Shibata, Tetsuo,Naito, Takanobu,Nakano, Jun,Maejima, Tetsuro,Senda, Hisato,Iwatani, Wakao,Tatsumi, Yoshiyuki,Suda, Masahiro,Arika, Tadashi
, p. 2833 - 2838 (2007/10/03)
The titled compounds were synthesized and evaluated for in vitro antibacterial activity. The (3R,4S)3-aminomethyl-4-trifluoromethyl derivative (S-34109) was confirmed to be optimal because of its superior activity against quinolone and methicillin-resistant Staphyrococcus aureus and low side effect potential.
