152212-38-9Relevant articles and documents
COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS
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, (2015/02/02)
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
Rhodium generated carbonyl ylides with p-quinones: Synthesis of oxa-bridged polycyclic systems
Muthusamy, Sengodagounder,Babu, Srinivasarao Arulananda,Gunanathan, Chidambaram,Suresh, Eringathodi,Dastidar, Parthasarathi,Jasra, Raksh Vir
, p. 7009 - 7019 (2007/10/03)
A series of α-diazo carbonyl compounds tethered to substituted cyclopentanone and cyclohexanone units with different tether lengths have been synthesized using diazomethane solution or methanesulphonyl azide. The above synthesized α-diazo carbonyl compounds with rhodium(II) acetate dimer furnish cyclic five- or six-membered-ring carbonyl ylide dipoles, which undergo facile 1,3-dipolar cycloaddition with p-quinones to furnish various novel oxa-bridged polycyclic systems 10, 13 and 11, 14 as C=C and C=O addition products of p-quinones. Very interesting unusual cyclization product, tri-oxapolycyclic compounds 12 and 15 were also obtained. Single-crystal X-ray analyses of 11a, 12d and 14a are reported to firmly establish the structure and stereochemistry of the oxa-bridged polycyclic systems. The molecules 11a and 14a exhibit novel C-H···O hydrogen bonding motif in the crystal structure. On the other hand, the molecule 12d revealed both O-H···O and C-H···O motifs in the solid-state architecture.