152235-94-4Relevant academic research and scientific papers
Synthesis and antiproliferative activity of some variously substituted acridine and azacridine derivatives
Ferlin, Maria Grazia,Marzano, Cristina,Chiarelotto, Gianfranco,Baccichetti, Francarosa,Bordin, Franco
, p. 827 - 837 (2000)
A group of 9-substituted acridine and azacridine derivatives (m-AMSA analogues) were synthesised following classical procedures as potential antitumour agents with inhibitory effects on DNA topoisomerase II. Some were found to have noticeable cytotoxicity against human HL-60 and HeLa cells grown in culture. Their non-covalent interactions with calf thymus DNA have been studied using fluorescence quenching. We evaluated DNA damage produced by the tested compounds by means of DNA filter elution and protein precipitation techniques. Catalytic studies carried out with purified topoisomerase confirmed these agents as antitopoisomerase inhibitors. Chemotherapy of solid-tumour-bearing mice with tested compounds allowed an aza-analogue (compound IIIb), as potent as m-AMSA but less toxic towards the host, to be recognised. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
New mono- and bis-intercalating compounds between DNA base pairs
Chiarelotto,Ferlin,Vedaldi,Dall'Acqua,Rodighiero
, p. 835 - 855 (2007/10/02)
With the aim to obtain new bis-intercalating agents in DNA a series of compounds was prepared linking two identical tricyclic moieties (two 4,5'-8-trimethylpsoralen (TMP)) or different (one TMP and one pyrido[3,2-b]quinoline) through a hydrocarburic amina
