1522406-17-2Relevant academic research and scientific papers
Oxidative synthesis of benzo[1,4]oxazines from α-branched primary amines and ortho-benzoquinones
Vasu, Dhananjayan,Leitch, Jamie A.,Dixon, Darren J.
, (2019)
The efficient oxidative construction of benzo[1,4]oxazines from simple α-branched amines and ortho-benzoquinones is reported. The procedure pivots on a triethylamine and iodine mediated oxidative ring closure from the ketimine intermediate formed upon their condensation. This reaction was shown to tolerate a variety of α-branched benzylamines and downstream derivatization to substituted benzomorpholine structures was also demonstrated.
