152253-28-6

Basic information

• Product Name: (R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-methanesulfonyl-ethyl) ester 5-methyl ester
• CAS NO: 152253-28-6
• Molecular Weight: 438.458
• Mol File: 152253-28-6.mol

Chemical Properties

• CAS DataBase Reference: (R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-methanesulfonyl-ethyl) ester 5-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-methanesulfonyl-ethyl) ester 5-methyl ester(152253-28-6)
• EPA Substance Registry System: (R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-methanesulfonyl-ethyl) ester 5-methyl ester(152253-28-6)

Safety Data

• Hazardous Substances Data: 152253-28-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 

Downstream Products

• 76093-34-0 (+)-(S)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid 

Relevant articles and documents

CARBAMOYLMETHYL GROUP AS AN ACTIVATED GROUP IN PROTEASE- AND BASE-CATALYZED TRANSESTERIFICATION OF 1,4-DIHYDROPYRIDINES: A NOVEL ASYMMETRIC SYNTHESIS OF VALNIDIPINE

The first protease-catalyzed enantioselective transesterification of 1,4-dihydropyridine-3,5-dicarboxylates in an aqueous solution was developed with high optical purity.Carbamoylmethyl ester group was enantioselectively transesterificated with (S)-N-benzyl-3-pyrroridinol by the protease and successive base-catalyzed transesterification proceeded smoothly to give the chiral drug, valnidipine, in a good yield.

PROTEASE-CATALYZED ENANTIOSELECTIVE SYNTHESIS OF OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINES

The first enantioselective protease-catalyzed hydrolyses of 1,4-dihydropyridine-3,5-dicarboxylic diesters were developed.The monoesters obtained had high optical purity and were useful building blocks which could easily lead to optically active Ca-blockers.