152297-24-0Relevant academic research and scientific papers
Enantioselective synthesis of 2-alkyl-2-cyanocycloalkanones with a quaternary stereogenic center
Enders,Zamponi,Raabe,Runsink
, p. 725 - 728 (2007/10/02)
2-Alkyl-2-cyanocycloalkanones 4 bearing a quaternary stereogenic center are synthesized in good overall yields and high enantiomeric excesses (ee = 90-95%) employing the SAMP-/RAMP-hydrazone method. The absolute configuration is confirmed by NMR-spectroscopic investigations on SAMP-hydrazone 3a and an X-ray structure analysis of SAMP-hydrazone 3f.
